中国免疫学杂志2025，Vol.41Issue(7)：1763-1767,5.DOI:10.3969/j.issn.1000-484X.2025.07.032
支气管肺泡灌洗液细胞学检查联合淋巴细胞免疫分析对卒中相关性肺炎危重患者临床疗效的影响
Impact of cytological examination of bronchoalveolar lavage fluid combined with lymphocyte immunoassay on clinical outcome of critically ill patients with stroke-associated pneumonia
摘要
Abstract
Objective:To investigate the effect of bronchoalveolar lavage fluid(BALF)cytology examination combined with lymphocyte immunoassay on clinical outcome of critically ill patients with stroke-associated pneumonia(SAP).Methods:One hundred and fifty-six critically ill patients with SAP admitted to Department of Respiratory and Critical Care Medicine of the Second People's Hospital of Weifang from September 2021 to June 2022 were selected,and randomly divided into a study group and a control group,with 78 cases in each group.Control group was treated with conventional pulmonary infection,and study group added bronchoscopic alveolar lavage treatment based on the treatment of control group,and the anti-infection treatment regimen was adjusted according to the results of BALF lymphocyte immunoassay.Clinical improvement rates,clinical symptom scores,serum inflammatory factors[procal-citonin(PCT),C-reactive protein(CRP),TNF-α],peripheral blood lymphocyte subsets(CD3+T,CD4+T,CD8+T)levels,treatment condition,in-hospital mortality and incidence of acute respiratory distress syndrome(ARDS)between the two groups were compared.Results:Clinical improvement rates were higher in study group(44.87%,58.97%,91.03%,97.44%)than that in control group(26.92%,42.31%,78.21%,88.46%)at 3 d,5 d,7 d and 10 d of treatment(P<0.05);serum PCT,CRP and TNF-α levels were lower in study group than that in control group after 10 d of treatment(P<0.05);peripheral blood CD3+T,CD4+T,CD8+T levels were higher in study group than that in control group after 10 d of treatment(P<0.05).CPIS and CURB-65 scores were lower in study group than that in control group after 10 d of treatment(P<0.05);duration of antimicrobial drug use,duration of mechanical ventilation,and length of hospital stay were shorter in study group than that in control group(P<0.05);in-hospital mortality rate(7.69%)and inci-dence of ARDS(5.13%)were lower in study group than that in control group(19.23%,15.38%)(P<0.05).Conclusion:Optimized anti-infection treatment plan based on BALF cytology examination combined with lymphocyte immunoassay can significantly improve clinical efficacy of critically ill patients with SAP,and help to promote recovery and improve the prognosis of patients.关键词
卒中相关性肺炎/危重患者/支气管肺泡灌洗液/细胞学检查/淋巴细胞免疫Key words
Stroke-associated pneumonia/Critical care patient/Bronchoalveolar lavage fluid/Cytology examination/Lymphocyte immunity分类
医药卫生引用本文复制引用
潘建亮,梁婷婷,侯建华..支气管肺泡灌洗液细胞学检查联合淋巴细胞免疫分析对卒中相关性肺炎危重患者临床疗效的影响[J].中国免疫学杂志,2025,41(7):1763-1767,5.基金项目
山东省医药卫生科技发展计划项目(202003021249). （202003021249）
