中国全科医学2025，Vol.28Issue(27)：3375-3384,3409,11.DOI:10.12114/j.issn.1007-9572.2024.0467
脂肪-肌肉比的年龄分层差异与高尿酸血症的相关性研究
Correlation Analysis between Age-Stratified Differences in Fat-to-muscle Ratio and Hyperuricemia
周鹏龙 1苌静 1丁素英 2陈静锋 2王涛 3李晨阳4
作者信息
- 1. 450000 河南省郑州市,郑州大学第一附属医院保健办公室
- 2. 450000 河南省郑州市,郑州大学第一附属医院健康管理中心
- 3. 450000 河南省郑州市,郑州大学第一附属医院泌尿外科
- 4. 450000 河南省郑州市,河南中医药大学第一附属医院呼吸内镜诊疗中心
- 折叠
摘要
Abstract
Background Fat to muscle ratio(FMR)is an emerging body composition indicator associated with a variety of health problems.However,the correlation between FMR and hyperuricemia(HUA)and their age-stratified differences are unclear.Objective To investigate the correlation between FMR and HUA,and their age-stratified differences.Methods A total of 2 137 volunteers receiving physical examination in the Physical Examination Center of the First Affiliated Hospital of Zhengzhou University from January to July 2024 were selected as the research objects.General information,laboratory examination and body composition indexes of the subjects were collected.Logistic regression analysis was used to investigate the effect of FMR on HUA.Restricted cubic spline model(RCS)was used to evaluate the dose-response correlation of age and FMR with HUA.Results A total of 395 subjects had HUA.RCS model showed that there was a nonlinear relationship between male age and HUA(Pnonlinear=0.014),and there was a linear relationship between female age and HUA(Pnonlinear=0.656).Logistic regression analysis showed that in Model 1,FMR at Q3-Q5 levels in the≤45 years old group was significantly correlated with an increased risk of HUA(P<0.05),while FMR in>45 years old group was not correlated with HUA(P>0.05).In Model 2 and 3,Q3-Q5 levels of FMR in the≤45 years old group were still significantly correlated with an increased risk of HUA,while only Q4-Q5 levels of FMR in the>45 years old group were significantly correlated with an increased risk of HUA(P<0.05).In addition,Q4 and Q5 levels of FMR in HUA patients≤45 years old were 2.98 times(95%CI=1.75-5.06)and 4.33 times(95%CI=2.42-7.75)of Q1 level,respectively.The risk in HUA patients>45 years old was reduced to 2.24(95%CI=1.04-4.84)and 3.50(95%CI=1.44-8.50),respectively.RCS model showed that there was a nonlinear relationship between FMR and HUA in men≤45 years old(Pnonlinear=0.028),and a linear relationship in men>45 years old(Pnonlinear=0.392).There was a linear relationship between FMR and the incidence of HUA in women≤45 years old(Pnonlinear=0.537),but no significant relationship between FMR and the incidence of HUA in women>45 years old(P>0.05).Conclusion FMR imbalance is an important risk factor for the onset of HUA,but its effect decreases with age.Our findings provide a new perspective for the prevention and management of HUA,and evidence-based evidence for the accurate management of age-stratified HUA.关键词
高尿酸血症/脂肪肌肉比/年龄因素/肌肉质量/体脂肪Key words
Hyperuricemia/Fat to muscle ratio/Age factors/Muscle mass/Body fat分类
医药卫生引用本文复制引用
周鹏龙,苌静,丁素英,陈静锋,王涛,李晨阳..脂肪-肌肉比的年龄分层差异与高尿酸血症的相关性研究[J].中国全科医学,2025,28(27):3375-3384,3409,11.
