中国全科医学2025，Vol.28Issue(27)：3385-3390,6.DOI:10.12114/j.issn.1007-9572.2024.0517
消化系统肿瘤血脂特征对正常相位角的预测价值研究
Research on the Predictive Value of Lipid Characteristics about Digestive System Tumors for Normal Phase Angles
摘要
Abstract
Background Lipids play a crucial role in maintaining normal physiological functions,and cancer patients often exhibit dyslipidemia,which can affect prognosis.Phase angle(PA)is an objective index reflecting the structural integrity and function of human cell membrane,which is positively correlated with the nutritional status of the body,and is often used to predict survival and therapeutic effect.Currently,the lipid profile characteristics of digestive system cancer patients and their impact on PA remain unclear.Objective To analyze the lipid profile characteristics of patients with digestive system tumors and investigate their influence on PA.Methods A retrospective study was conducted on 142 patients admitted to the Affiliated Anqing First People's Hospital of Anhui Medical University between July 2020 and December 2023.General patient data,performance status(PS)scores and patient-generated subjective global assessment(PG-SGA)scores were collected.Lipid profile indicators and PA were measured,and patients were divided into a normal PA group and a low PA group based on PA levels.Differences in general characteristics and lipid levels between the two groups were compared.Binary logistic regression was used to analyze the influencing factors of PA.Receiver operating characteristic(ROC)curves were plotted,and the area under the ROC curve(AUC)was calculated to evaluate the predictive value of lipid indicators for PA.Results Among the 142 patients,104(73.24%)were male,and 38(26.76%)were female,with a mean age of(65.0±10.8)years.The low PA group comprised 64 patients(45.07%),while the normal PA group included 78 patients(54.93%).Significant differences were observed between the two groups in terms of sex,age,PS score and PG-SGA score(P<0.05).The low PA group had lower levels of total cholesterol(TC),triacylglycerol(TG)and low density lipoprotein(LDL)compared to the normal PA group(P<0.05),while no significant difference was found in high density lipoprotein(HDL)levels(P>0.05).Binary Logistic regression analysis revealed that female sex(OR=0.251,95%CI=0.086-0.731)and age>65(OR=0.281,95%CI=0.108-0.727)were protective factors for PA≥4.4°,whereas TC(OR=6.142,95%CI=2.795-13.494)was a risk factor for PA≥4.4°.The AUC for TC in predicting PA≥4.4° was 0.803(95%CI=0.733-0.874),with a sensitivity of 75.6%,specificity of 71.9%,and an optimal cutoff value of 4.25 mmol/L.The AUC for LDL in predicting PA≥4.4°was 0.790(95%CI=0.717-0.863),with a sensitivity of 76.9%,specificity of 67.2%,and an optimal cutoff value of 2.46 mmol/L.The AUC for TG in predicting PA≥4.4° was 0.609(95%CI=0.517-0.702),with a sensitivity of 55.1%,specificity of 64.1%,and an optimal cutoff value of 1.05 mmol/L.Conclusion Lipid metabolism in digestive system tumor patients is influenced by multiple factors.The levels of TC and LDL have a relatively high predictive value for PA≥4.4 °.Controlling both levels within an appropriate range(TC:4.25-5.55 mmol/L,LDL:2.46-3.91 mmol/L)is conducive to maintaining normal PA and may potentially improve prognosis.关键词
消化系统肿瘤/血脂/相位角/营养状态/Logistic回归分析Key words
Digestive system tumors/Blood lipid/Phase angle/Nutritional status/Logistic regression analysis分类
医药卫生引用本文复制引用
朱晨,余嘉文,江昊,甘盼盼,夏天,徐海涛,杜瀛瀛..消化系统肿瘤血脂特征对正常相位角的预测价值研究[J].中国全科医学,2025,28(27):3385-3390,6.基金项目
安徽医科大学校基金项目(2022xkj230) （2022xkj230）
