中国塑料2025，Vol.39Issue(7)：6-11,6.DOI:10.19491/j.issn.1001-9278.2025.07.002
疫苗佐剂用阳离子聚乳酸纳微颗粒的制备及调控研究
Study on preparation and regulation of cationic polylactic acid nano-microparticles for vaccine adjuvant
赵晓欢 1王岩森 1孙靖山 1邓静倩 1祁丽亚 1侯丹丹 1王春堯 1谈心妤1
作者信息
- 1. 中石化(北京)化工研究院有限公司,北京 100013
- 折叠
摘要
Abstract
DDAB-PLA nano-microparticles were synthesized via an improved emulsification method,with particle size controlled by adjusting the oil/water phase ratio and emulsifier concentration.The cytotoxicity of DDAB-PLA particles with varying cationic contents was also evaluated.The resulting particles exhibited a nano-to micro-scale size distribu-tion,with an average diameter of approximately 490 nm.By modulating the aqueous phase volume and emulsifier con-centration,the particle size could be precisely tuned within the range of 169～786 nm.Furthermore,DDAB-PLA nano-microparticles demonstrated negligible cytotoxicity toward L929 cells and DC,indicating excellent biocompatibility.关键词
聚乳酸/乳化法/纳微颗粒/颗粒尺寸/疫苗佐剂Key words
polylactic acid/emulsification method/nano-microparticle/particle size/vaccine adjuvant分类
化学化工引用本文复制引用
赵晓欢,王岩森,孙靖山,邓静倩,祁丽亚,侯丹丹,王春堯,谈心妤..疫苗佐剂用阳离子聚乳酸纳微颗粒的制备及调控研究[J].中国塑料,2025,39(7):6-11,6.
