中国输血杂志2025，Vol.38Issue(7)：879-885,7.DOI:10.13303/j.cjbt.issn.1004-549x.2025.07.003
血液成分输注对脓毒血症患者预后的影响因素分析
Analysis of prognosis and influencing factors of sepsis patients receiving blood component transfusion
摘要
Abstract
Objective To identify influencing factors associated with the prognosis of sepsis patients receiving blood component transfusion,and to provide a more rational and scientific transfusion strategy for clinical management.Methods Clinical data of 232 patients with sepsis treated at the Second Xiangya Hospital of Central South University between Janu-ary 2022 and December 2023 were retrospectively analyzed.These patients were categorized into the transfusion group(n=64)and the non-transfusion group(n=168)based on whether they received transfusions,and the patients in the transfu-sion group were further divided into non-survivor group(n=26)and survivor group(n=38)based on their survival out-come.Baseline characteristics and clinical characteristics were compared between two groups.Factors impacting the progno-sis of sepsis patients undergoing blood component transfusion were identified using logistic regression.Results Compared to the non-transfusion group,the transfusion group showed significantly higher levels of coagulation indicators(prothrombin time,activated partial thromboplastin time,international normalized ratio,D-dimer)and inflammatory markers(C-reactive protein,procalcitonin,interleukin-6),while the level of hemoglobin,platelet,lymphocyte,fibrinogen,albumin,blood glucose,and oxygen saturation were significantly lower(P<0.05).The[M(P25,P75)]for C-reactive protein(mg/L),he-moglobin(g/L),and platelet count(×109/L)in the transfusion vs non-transfusion groups were 178.0(156.1-178)vs 102.7(74.0-119.6),88.5(72.3-113.0)vs 110.5(101-121.8),and 63.0(26.5-156.5)vs 202.5(108.3-286.8),respectively(all P<0.05).Logistic regression analysis revealed that hemoglobin level,platelet count,lactate concentra-tion,and the storage duration of transfused red blood cells were independent risk factors affecting the survival outcomes of sepsis patients receiving transfusions(P<0.05).In septic transfusion patients,the[M(P25,P75)]lactate concentration(mmol/L)and RBC storage time(d)in the non-survivor vs survivor groups were 3.5(1.9-7.7)vs 2.1(1.3-3.5),18.0(13.0-18.0)vs 12.0(9.0-14.0),respectively(both P<0.05).Conclusion Compared to non-transfused sepsis pa-tients,those receiving transfusions exhibited poorer baseline conditions,more severe infections,and worse survival out-comes.More importantly,the study found that the timing of transfusion decisions and the quality control of blood products(such as storage duration)may directly impact patient prognosis,providing critical evidence for optimizing transfusion strat-egies in septicemia patients.关键词
脓毒血症/血液成分输注/预后影响Key words
sepsis/blood component transfusion/prognosis influence分类
医药卫生引用本文复制引用
赵冰洁,操博为,朱远裴,张宁洁..血液成分输注对脓毒血症患者预后的影响因素分析[J].中国输血杂志,2025,38(7):879-885,7.基金项目
国家自然科学基金项目(82102281) （82102281）
湖南省自然科学基金青年项目(2021JJ40893) （2021JJ40893）
