中国输血杂志2025，Vol.38Issue(7)：909-914,6.DOI:10.13303/j.cjbt.issn.1004-549x.2025.07.007
ABO非同型少浆单采血小板输注的安全性及有效性评价
Evaluation of the safety and efficacy of ABO non-identical apheresis platelets with reduced plasma transfusion
摘要
Abstract
Objective To evaluate the safety and efficacy of ABO non-identical platelets with reduced plasma(ABO-NPRP)transfusion in patients with hematological diseases.Methods A retrospective analysis was conducted on 52 thera-peutic doses of apheresis platelets with reduced plasma prepared at Chongqing Blood Center of the Chinese People's Libera-tion Army.The transfusion efficacy(24 h CCI)and the transfusion adverse reactions of these apheresis platelets were also observed in 35 patients with hematological diseases in First Affiliated Hospital of Army Medical University.Comparisons were made with a control group consisting of patients who received only identical apheresis platelets during the same period.Meanwhile,the effect of ABO-NPRP on the subsequent platelet transfusion efficacy was observed.Results There was no statistically significant difference in PDW,MPV,and PLCR before and after the preparation of apheresis platelets with re-duced plasma(P>0.05),while the difference in platelet count was statistically significant[(2.86±0.34)×1011 per thera-peutic dose vs(2.46±0.28)×1011 per therapeutic dose,P<0.001];there was no statistically significant difference in the 24 h CCI transfusion efficacy between conventional identical apheresis platelets and ABO-NPRP,with transfusion efficacy rates of 76.60%and 78.85%,respectively(P>0.05);there was no statistically significant difference in platelet transfu-sion efficacy between the group with ABO-NPRP and the group without ABO-NPRP(completely identical transfusion group),with transfusion efficacy rates of 77.78%and 75.25%,respectively(P>0.05).Conclusion ABO-NPRP trans-fusion is safe,effective,demonstrating comparable efficacy to conventional identical transfusion.It can serve as an impor-tant complementary strategy to optimize the utilization of blood resources.关键词
ABO血型/非同型血小板/非同型少浆血小板/血小板输注/输注疗效Key words
ABO blood group/non-identical platelets/non-identical platelets with reduced plasma/platelet transfu-sion/transfusion efficacy分类
医药卫生引用本文复制引用
刁荣华,阮潜瑛,白璐,张红,王泽蓉,付蕾,王世春..ABO非同型少浆单采血小板输注的安全性及有效性评价[J].中国输血杂志,2025,38(7):909-914,6.基金项目
国家自然科学基金(81700180) （81700180）
重庆市自然科学基金(cstc2021jcyj-msxmX0702) （cstc2021jcyj-msxmX0702）
