中国输血杂志2025，Vol.38Issue(7)：922-927,6.DOI:10.13303/j.cjbt.issn.1004-549x.2025.07.009
β-内酰胺类抗生素相关的药物性抗体检测及临床分析
Detection and clinical analysis of drug-induced antibodies related to β-lactam antibiotics
摘要
Abstract
Objective To investigate the positive rate of drug-induced antibodies produced by the clinical application of β-lactam antibiotics,and analyze the differences in the detection methods and related influencing factors.Methods A total of 350 adult inpatients who developed anemia after using β-lactam antibiotics for 3 days or more in Inner Mongolia People's hospital were selected as the experimental group,and 240 adult inpatients treated with β-lactam antibiotics for 3 days or more who did not develop anemia as the control group.The drug-induced antibody tests,direct antiglobulin tests,and unex-pected antibody screening were performed on both groups,and the influencing factors of drug-induced antibodies were ana-lyzed.Results The numbers of positive cases of drug-induced antibody detected by the drug-coated red blood cell method in the experimental group and the control group were 12(12/350,3.43%)and 2(2/240,0.83%)respectively,with statis-tically significant differences(P<0.05).No drug-induced antibodies were detected in either group using the drug addition method.In the experimental group,the red blood cell method detected β-lactam drug-induced antibodies in 12 cases(12/350,3.43%),while the drug added method detected 0 cases(0/350,0.00%),with statistically significant differences(P<0.05).In the control group,the detection rates of two methods showed no statistically significant difference(P>0.05).In the experimental group,7 cases of β-lactam antibodies were detected in the cephalosporin group(7/293,2.40%)and 5 cases in the non-cephalosporin group(5/58,8.62%),with statistically significant differences(P<0.05).There was no statistically significant difference between the second-generation and third-generation cephalosporin drugs(P>0.05).When the experimental group was stratified according to the history of blood transfusion and the blood type of patients,no statisti-cally significant differences were observed between subgroups(P>0.05).Conclusion Anemia may be related to the pro-duction of drug-induced antibodies followingβ-lactam antibiotics treatment.Therefore,improving the clinical awareness of drug-induced antibodies to β-lactam antibiotics is of great significance to clarify the causes of anemia and reduce unnecessa-ry blood transfusions.关键词
药物性抗体/β-内酰胺类抗生素/贫血/药物诱导的免疫性溶血性贫血Key words
drug-induced antibodies/β-lactam antibiotics/anemia/drug-induced immunohemolytic anemia分类
医药卫生引用本文复制引用
郑洋洋,王荣鹏,赵洁,禚秉政,陈凤..β-内酰胺类抗生素相关的药物性抗体检测及临床分析[J].中国输血杂志,2025,38(7):922-927,6.基金项目
内蒙古自治区卫生健康科技计划项目(202201022) （202201022）
