中国现代医学杂志2025，Vol.35Issue(15)：31-37,7.DOI:10.3969/j.issn.1005-8982.2025.15.005
PAI-1基因多态性与糖尿病肾病患者并发脑梗死的关系研究
Association between PAI-1 gene polymorphisms and cerebral infarction in patients with diabetic nephropathy
摘要
Abstract
Objective To investigate the relationship between plasminogen activator inhibitor-1(PAI-1)gene polymorphisms(4G/5G)and cerebral infarction(CI)in patients with diabetic nephropathy(DN).Methods Data from 149 DN patients admitted between January 2020 and December 2023 were reviewed:68 with CI(CI group)and 81 without CI(non-CI group).PAI-1 4G/5G genotype and allele frequencies were determined.Clinical and laboratory data were compared.Multivariate logistic regression identified CI risk factors.ROC analysis evaluated the predictive value of PAI-1 polymorphisms alone and combined with other factors.Results Genotype(4G/4G,4G/5G,5G/5G)and allele(4G,5G)distributions differed significantly between groups(P<0.05).The CI group had a higher frequency of the 4G/4G genotype and 4G allele(P<0.05).The CI group had longer dialysis vintage,higher TC,LDL-C,fibrinogen,homocysteine levels,and lower urea clearance index(Kt/V)(P<0.05).Multivariate analysis identified 4G/4G genotype[((O^R))=5.859(95%CI:2.003,17.142)],longer dialysis vintage[((O^R))=4.545(95%CI:1.870,11.046)],and high LDL-C[((O^R))=3.951(95%CI:1.626,9.603)]as independent risk factors for CI.ROC analysis showed sensitivities for dialysis vintage,LDL-C,PAI-1 polymorphism,and their combination predicting CI were 77.78%(95%CI:0.676,0.853),87.65%(95%CI:0.782,0.921),85.19%(95%CI:0.750,0.921),and 92.59%(95%CI:0.853,0.964),respectively.Specificities were 75.00%(95%CI:0.647,0.833),70.59%(95%CI:0.600,0.800),67.65%(95%CI:0.562,0.781),and 85.29%(95%CI:0.765,0.914),respectively.AUCs were 0.810(95%CI:0.740,0.880),0.853(95%CI:0.790,0.916),0.764(95%CI:0.684,0.844),and 0.939(95%CI:0.900,0.978),respectively.Conclusion The PAI-1 4G/4G genotype,dialysis vintage,and LDL-C are associated with CI in DN patients.Their combination demonstrates excellent predictive performance.关键词
糖尿病肾病/脑梗死/纤溶酶原激活剂抑制物-1/基因多态性Key words
diabetic nephropathy/cerebral infarction/plasminogen activator inhibitor-1/gene polymorphism分类
医药卫生引用本文复制引用
张红月,贾晶,刘艳鑫..PAI-1基因多态性与糖尿病肾病患者并发脑梗死的关系研究[J].中国现代医学杂志,2025,35(15):31-37,7.基金项目
黑龙江省卫生健康委科研课题(No:20230303050025) （No:20230303050025）
