中国现代医学杂志2025，Vol.35Issue(15)：52-57,6.DOI:10.3969/j.issn.1005-8982.2025.15.008
空间代谢组学在肾脏疾病中的研究进展
Research progress of spatial metabolomics in kidney diseases
摘要
Abstract
Kidney diseases pose a major global health burden with high incidence and mortality.Early stages often lack symptoms,leading to significant damage before detection.Current research on early diagnostic biomarkers relies on genomics,proteomics,and transcriptomics,but these methods lack spatial and temporal information.Metabolomics shows increasing potential for identifying disease mechanisms,aiding diagnosis,and developing treatments for kidney diseases.Spatial metabolomics,the latest addition to the omics toolkit,enables in situ mass spectrometry analysis of fresh tissue,preserving spatial and temporal information.This review summarizes the progress of spatial metabolomics in kidney disease research,including understanding diabetic nephropathy pathogenesis and differentiating renal cell carcinoma from normal tissue.关键词
肾脏疾病/糖尿病肾病/空间代谢组学/质谱成像Key words
kidney diseases/diabetic nephropathy/spatial metabolomics/mass spectrometry imaging分类
医药卫生引用本文复制引用
梁梦雨,万凤,张煊,朱勤..空间代谢组学在肾脏疾病中的研究进展[J].中国现代医学杂志,2025,35(15):52-57,6.基金项目
国家自然科学基金(No:82205008) （No:82205008）
浙江省卫生厅项目(No:2023RC242) （No:2023RC242）
