中国现代医学杂志2025，Vol.35Issue(15)：58-62,5.DOI:10.3969/j.issn.1005-8982.2025.15.009
孟德尔随机化在糖尿病肾病中的研究进展
Research progress of Mendelian randomization in diabetic kidney disease
摘要
Abstract
Mendelian randomization(MR),a causal inference method using genetic variants as instrumental variables,leverages the random allocation of alleles at conception to minimize confounding and reverse causation inherent in observational studies.Recently,MR has gained prominence.Diabetic kidney disease(DKD),a major microvascular complication of diabetes and leading cause of end-stage renal disease,has a complex pathogenesis involving multiple factors.Current understanding largely stems from observational studies lacking robust causal evidence.This review summarizes the application and progress of MR in DKD research,aiming to provide new insights for DKD treatment.关键词
糖尿病肾病/孟德尔随机化/研究进展/糖尿病并发症/遗传变异Key words
diabetic kidney disease/Mendelian randomization/research progress/complications of diabetes/genetic variation分类
医药卫生引用本文复制引用
王远馨,邱佳琪,双岩,刘影哲..孟德尔随机化在糖尿病肾病中的研究进展[J].中国现代医学杂志,2025,35(15):58-62,5.基金项目
黑龙江省自然科学基金(No:PL2024H214) （No:PL2024H214）
黑龙江省中医药管理局中医药科研课题项目(No:ZHY2022-156) （No:ZHY2022-156）
黑龙江中医药大学附属第一医院国家自然科学基金培育支持计划(No:PYMS202501012) （No:PYMS202501012）
