中国现代医学杂志2025，Vol.35Issue(15)：63-67,5.DOI:10.3969/j.issn.1005-8982.2025.15.010
知柏强骨汤治疗肝肾亏虚型膝关节骨性关节炎的临床疗效观察
Clinical observation on the efficacy of Zhibai Qianggu Decoction in treating knee osteoarthritis with liver-kidney deficiency
摘要
Abstract
Objective To evaluate the therapeutic effect of Zhibai Qianggu Tang(ZBQGT)on knee osteoarthritis(KOA)with liver and kidney deficiency syndrome(LKDS).Method Eighty KOA patients with LKDS diagnosed between January 2021 and March 2024 were randomized into a control group(n=40,conventional treatment)and a treatment group(n=40,conventional treatment+ZBQGT).Clinical efficacy,knee joint mobility,Traditional Chinese Medicine(TCM)syndrome scores,bone metabolism markers(TRACP,CTX-I,BGP,OPG),and inflammation markers(IL-1,IL-6,TNF-α,ESR)were compared.Results The total effective rate was significantly higher in the treatment group(P<0.05).Improvements in knee extension,flexion,range of motion,and TCM syndrome scores were significantly greater in the treatment group(P<0.05).Changes in TRACP,CTX-I,BGP,and OPG levels were more favorable in the treatment group(P<0.05).Decreases in IL-1,IL-6,TNF-α,and ESR were significantly greater in the treatment group(P<0.05).Conclusion Zhibai Qianggu Decoction combined with conventional treatment demonstrates significant clinical efficacy in KOA patients with liver-kidney deficiency,improving joint function,bone metabolism,and reducing inflammation.关键词
膝关节骨性关节炎/肝肾亏虚/知柏强骨汤/临床疗效Key words
knee osteoarthritis/liver-kidney deficiency/Zhibai Qianggu decoction/clinical efficacy分类
医药卫生引用本文复制引用
孔帅,朱临潼,苗新旗..知柏强骨汤治疗肝肾亏虚型膝关节骨性关节炎的临床疗效观察[J].中国现代医学杂志,2025,35(15):63-67,5.基金项目
江苏省自然科学基金青年项目(No:BK20230453) （No:BK20230453）
