中国循证儿科杂志2025，Vol.20Issue(3)：181-184,4.DOI:10.3969/j.issn.1673-5501.2025.03.004
单中心伴8号染色体三体的原发性急性髓系白血病患儿47例病例系列报告
Primary acute myeloid leukemia with trisomy 8 chromosomes in 47 children:A case series report in a single-center study
摘要
Abstract
Background Trisomy of chromosome 8(+8)in adult acute myeloid leukemia(AML)is typically associated with intermediate or poor prognosis,but its clinical significance in children with AML is limited.Objective To investigate the clinical characteristics,early treatment outcomes,and prognostic outcomes of children with+8 AML.Design Case series report.Methods Clinical data of children with+8 AML diagnosed at Peking University People's Hospital from January 2009 to December 2023 were included.The study analyzed their clinical characteristics,cytogenetic features,complete remission(CR)after induction chemotherapy,overall survival(OS).The binary logistic regression model was used to analyze the factors related to CR.The Kaplan-Meier method and log-rank test were used for survival analysis,and the Cox regression model was used for the analysis of factors related to OS.Main outcome measures CR after induction chemotherapy and OS.Results Among the 812 children with de novo AML during the period,there were 48 children with+8 AML,accounting for 5.9％.A total of 47 children were included in the study(excluding 1 child who did not complete induction chemotherapy),with 17 females(36.2％)and a median age of 9 years.There were 11 children(23.4％)with isolated+8 AML and 36 children(76.6％)with additional chromosomal abnormalities.According to the 2020 European LeukemiaNet(ELN)AML risk stratification criteria,there were 15 chilren in the group with favorable genetic abnormalities,17 children with intermediate genetic abnormalities,and 15 children with unfavorable genetic abnormalities.The most common chromosomal abnormality was KMT2A rearrangement(19.1％),and the most common gene mutation was FLT3-ITD(29.8％).CR was achieved in 30 children(63.8％)after induction chemotherapy,and multivariate analysis found that the presence of unfavorable genetic abnormalities was an independent risk factor for CR(HR=0.13,95％CI:0.02～0.93).The median survival time was 40 months,with a 3-year OS of(77.8±6.2)％,and no independent factors affecting OS were identified.Conclusion The incidence of+8 chromosomes in children with AML is lower than that in adults and children from abroad.Children with+8 AML are prone to be combined with additional genetic abnormalities.Those with unfavorable genetic abnormalities are less likely to achieve CR after induction chemotherapy,while no independent factors affecting OS were found.关键词
8号染色体三体/儿童/急性髓系白血病Key words
Trisomy 8 chromosomes/Children/Acute myeloid leukemia引用本文复制引用
郑方圆,王淼,陆爱东,贾月萍,张乐萍,曾慧敏..单中心伴8号染色体三体的原发性急性髓系白血病患儿47例病例系列报告[J].中国循证儿科杂志,2025,20(3):181-184,4.基金项目
国家自然科学基金:82000151 （）
北京大学人民医院研究与发展基金:RZ 2023-04 （）
