中国医科大学学报2025，Vol.54Issue(7)：638-642,5.DOI:10.12007/j.issn.0258-4646.2025.07.011
前列腺素D2受体对肺腺癌细胞增殖、迁移及自噬的影响
Effect of PTGDR2 on the proliferation,migration,and autophagy of lung adenocarcinoma cells
陈熹铭 1吴岑2
作者信息
- 1. 中国医科大学附属盛京医院肿瘤多组学研究创新实验室,辽宁 本溪 117004
- 2. 中国医科大学附属盛京医院呼吸与危重症医学科,沈阳 110004
- 折叠
摘要
Abstract
Objective To investigate the role of PTGDR2 in the progression of lung adenocarcinoma(LUAD)and its potential as a thera-peutic target in regard to regulating tumor stemness via autophagy.Methods In vitro experiments were conducted by silencing PTGDR2 with siRNA and treating LUAD A549 cells with PGD2 in order to evaluate its effects on cell proliferation,invasion,and stem cell marker expression.Autophagy regulation was further verified by rapamycin treatment.Results Activation of PTGDR2 signaling inhibited A549 cell proliferation and invasion,induced the upregulation of autophagy markers,and reduced the expression of stem cell markers.In con-trast,silencing PTGDR2blocked autophagy and enhanced tumor stemness.Conclusion PTGDR2 inhibits tumor stemness through the activation of autophagy,and therefore has potential as a therapeutic target to overcome drug resistance in LUAD.关键词
前列腺素D2受体/肺腺癌/肿瘤干细胞/自噬Key words
PTGDR2/lung adenocarcinoma/cancer stem cell/autophagy分类
医药卫生引用本文复制引用
陈熹铭,吴岑..前列腺素D2受体对肺腺癌细胞增殖、迁移及自噬的影响[J].中国医科大学学报,2025,54(7):638-642,5.
