中国药理学通报2025，Vol.41Issue(8)：1401-1406,6.DOI:10.12360/CPB202411031
促血管生成因子调控类风湿关节炎血管翳生成的分子机制及中药干预作用
Molecular mechanism of pro-angiogenic factors regulating pannus of rheumatoid arthritis and role of traditional Chinese medicine intervention
摘要
Abstract
Infiltration of a large number of inflammatory cells in the synovial tissue of rheumatoid arthritis(RA)promotes vascu-lar neovascularisation and the formation of aggressive pannus,which ultimately lead to bone erosion and cartilage destruction,causing irreversible damage to the joints.Numerous studies have demonstrated the role of proangiogenic factors such as growth factors,adhesion factors,angiopoietin 2,matrix metalloproteinas-es,and macrophage migration inhibitory factors in stimulating vascular opacification formation during RA progression.In re-cent years,a variety of traditional Chinese medicines have dem-onstrated inhibitory effects on the formation of pannus.In this paper,we elucidate the mechanism of pro-angiogenic factors in RA and review the latest research results on traditional Chinese medicines that inhibit the formation of pannus through the above mechanisms,so as to provide more research ideas for the treat-ment of RA.关键词
类风湿关节炎/血管翳/促血管生成因子/中药/分子机制/干预作用Key words
rheumatoid arthritis/pannus/pro-angiogenic fac-tors/traditional Chinese medicines/molecular mechanism/in-tervention分类
医药卫生引用本文复制引用
胡泽玉,赵芳,陈晶,林也,蔡雄,刘良..促血管生成因子调控类风湿关节炎血管翳生成的分子机制及中药干预作用[J].中国药理学通报,2025,41(8):1401-1406,6.基金项目
国家自然科学基金资助项目(No 82274506,82405235) （No 82274506,82405235）
湖南省自然科学基金资助项目(No 2024JJ5298,2023JJ40477) （No 2024JJ5298,2023JJ40477）
