中国药理学通报2025，Vol.41Issue(8)：1413-1418,6.DOI:10.12360/CPB202408005
中医药干预HuR转录后调控的抗肿瘤作用研究进展
Research progress on anti-tumor effect of traditional Chinese medicine intervention on post-transcriptional regulation of HuR
摘要
Abstract
Cancer is the main cause of death,and drug therapy has greatly improved the effectiveness of anti-tumor treatment.However,there are problems such as high adverse reactions and the risk of developing drug resistance after long-term use.There is an urgent need to seek new drug targets.Human antigen R(HuR),as an RNA binding protein,promotes the whole process of tumor occurrence,development and metastasis through post transcriptional regulation of mRNA stability,and HuR is general-ly highly expressed in tumor tissue,making it a new target for an-ti-tumor therapy and a standard for prognosis evaluation.Tradi-tional Chinese medicine formulas and their various chemical components can inhibit tumor proliferation,induce tumor cell ap-optosis,inhibit angiogenesis,suppress immune escape,and re-verse tumor drug resistance by regulating HuR activity.This re-view summarizes the importance of HuR in regulation of tumor progression,as well as analyzes the mechanisms of the antitumor effects through active ingredients of Chinese medicine with the regulation of HuR.It is expected to provide new ideas for tumor therapy and guidance for the development of HuR-targeted anti-tumor drugs.关键词
肿瘤/人类抗原R/转录后调控/mRNA稳定性/中药/分子机制Key words
tumor/HuR/post-transcriptional regulation/mR-NA stability/traditional Chinese medicine/molecular mecha-nism分类
医药卫生引用本文复制引用
杨柳青,李伟霞,王晓艳,张明亮,张辉,吴娅丽,唐进法..中医药干预HuR转录后调控的抗肿瘤作用研究进展[J].中国药理学通报,2025,41(8):1413-1418,6.基金项目
国家自然科学基金资助项目(No 82204838) （No 82204838）
河南省医学科技攻关计划省部共建项目(No SBGJ202302100) （No SBGJ202302100）
河南省卫生健康委国家中医临床研究基地科研专项(No 2022JDZX103) （No 2022JDZX103）
河南省高校科技创新团队(No 23IRTSTHN026) （No 23IRTSTHN026）
