中国药理学通报2025，Vol.41Issue(8)：1424-1431,8.DOI:10.12360/CPB202407002
靶向线粒体质量控制防治缺血性脑卒中及其中医药治疗进展
Advances in targeting mitochondrial quality control against ischemic stroke and its herbal medicine therapy
摘要
Abstract
Ischemic stroke is a sudden neurological disorder caused by local cerebral ischemia and persistent cerebral infarc-tion due to impaired blood supply of the brain.IS,with a high disability and mortality rate,is a high incidence disease in Chi-na.Mitochondria play a central role in the pathological and physiological processes of IS.Mitochondrial quality control(MQC)is the cornerstone of maintaining mitochondrial function and the integrity of mitochondrial network,playing an indispen-sable role in promoting neuronal survival and restoring neural vascular unit homeostasis after IS.IS belongs to stroke in tradi-tional Chinese medicine,and is the first of the four major diffi-cult diseases of"stroke,phthisis,swell,and dysphagia".The syndrome of IS belongs to the deficiency in origin and excess in superficies.Traditional Chinese medicine has thousands of years of experience in treating ischemic stroke.Numerous pharmaco-logical studies have found that the therapeutic effect of traditional Chinese medicine on ischemic stroke is closely related to the mechanism of mitochondrial quality control.Therefore,this arti-cle provides a review of the mechanism of MQC in IS and tradi-tional Chinese medicine targeted intervention for MQC,in order to provide reference and inspiration for new treatment for IS.关键词
线粒体质量控制/中风/缺血性脑卒中/中医药/作用机制/研究进展Key words
mitochondrial quality control/stroke/ischemic stroke/traditional Chinese medicine/mechanism/research pro-gress分类
医药卫生引用本文复制引用
张怡,代传朕,高维娟..靶向线粒体质量控制防治缺血性脑卒中及其中医药治疗进展[J].中国药理学通报,2025,41(8):1424-1431,8.基金项目
国家自然科学基金青年基金项目(No 82104963) （No 82104963）
河北省中医药管理局科研计划项目(No 2024336) （No 2024336）
河北中医药大学燕赵医学研究项目(No YZZY2023001) （No YZZY2023001）
