中国药理学通报2025，Vol.41Issue(8)：1431-1435,5.DOI:10.12360/CPB202411001
外泌体对糖尿病脑病的调控作用及中医药干预研究进展
Research progress in regulation of exosomes on diabetes encephalopathy and intervention of traditional Chinese medicine
摘要
Abstract
Diabetic encephalopathy(DE)is a complication of the central nervous system induced by diabetes,characterized by insidious onset and complex pathological mechanisms.Recent research has revealed that the pathological mechanisms of DE are closely associated with the imbalance of intercellular communica-tion across multiple organs.Exosomes,serving as vital media-tors of intercellular communication,are involved in the patholog-ical progression of DE and hold promise as diagnostic biomarkers and therapeutic targets for DE.Traditional Chinese medicine(TCM)can improve communication between brain cells and be-tween peripheral and brain tissues by regulating exosomes and their contents,thereby preventing and treating DE.Meanwhile,exosomes,as targeted delivery carriers of active molecules,can carry TCM monomers more easily across the blood-brain barrier to prevent and treat DE.In light of this,this review summarizes the regulatory role of exosomes in the pathological progression of DE and explores the enormous potential of TCM in the preven-tion and treatment of DE by regulating exosomes and using exo-somes as traditional Chinese medicine carriers,aiming to pro-vide new evidence for the prevention and treatment of DE with TCM.关键词
糖尿病脑病/细胞通讯/外泌体/微小RNA/中医药/递送载体Key words
diabetic encephalopathy/cell communication/exo-somes/microRNA/traditional Chinese medicine/delivery vec-tor分类
医药卫生引用本文复制引用
步洁,李英,林雪玲,庄朋伟,张艳军,尹清晟..外泌体对糖尿病脑病的调控作用及中医药干预研究进展[J].中国药理学通报,2025,41(8):1431-1435,5.基金项目
国家自然科学基金资助项目(No 82174112) （No 82174112）
现代中医药海河实验室科技项目(No 22HHZYSS00015) （No 22HHZYSS00015）
