中国药理学与毒理学杂志2025，Vol.39Issue(7)：527-537,11.DOI:10.3867/j.issn.1000-3002.2025.08323
单核源性免疫细胞及其分泌的细胞因子影响乳腺癌发展和转移的作用机制研究进展
Mechanism progress of monocyte-derived immune cells and their secreted cytokines on development and metastasis of breast cancer
摘要
Abstract
Breast cancer is a highly prevalent malignant tumor among women worldwide,and its clinical treatment faces significant challenges,such as high postoperative recurrence rates,high metas-tasis rates,and therapeutic resistance.Studies indicate that monocyte-derived immune cells play a critical role in promoting breast cancer progression by establishing an immunosuppressive tumor microenviron-ment and pre-metastatic niche.Monocytic myeloid-derived suppressor cells,tumor-associated macro-phages,and monocyte-derived dendritic cells secrete various cytokines,including interleukins,colony-stimulating factors,tumor necrosis factor,chemokines C-C motif chemokine ligand/C-X-C motif chemo-kine ligand(CCL/CXCL),and growth factors,which activate multiple signaling pathways and promote the development of breast cancer and its metastasis to such organs as bones,lungs,brains and livers through mechanisms involving CCL/CXCL-mediated recruitment,angiogenesis induction,and immune evasion.Therefore,targeting the regulation of monocyte-derived immune cells and their secreted cyto-kines may become a crucial therapeutic approach to breast cancer.This review summarizes the mech-anisms by which monocyte-derived immune cells and their cytokines contribute to the development and metastasis of breast cancer by exploring.It further explores therapeutic strategies targeting these cells and cytokines,such as modulating phenotypic transformation,reprogramming cellular metabolism,and regulating cytokine expression levels.关键词
单核源性免疫细胞/乳腺癌发展/乳腺癌转移/细胞因子/免疫调节/肿瘤微环境Key words
monocyte-derived immune cells/breast cancer progression/breast cancer metastasis/cytokine/immune regulation/tumor microenvironment分类
医药卫生引用本文复制引用
陈湘诺,叶宇豪,马宁辉,熊阳..单核源性免疫细胞及其分泌的细胞因子影响乳腺癌发展和转移的作用机制研究进展[J].中国药理学与毒理学杂志,2025,39(7):527-537,11.基金项目
国家自然科学基金(82174095) （82174095）
杭州市自然科学基金(2024SZRZDC200001) （2024SZRZDC200001）
浙江省中医药科技计划(2023ZL362) National Natural Science Foundation of China(82174095) （2023ZL362）
Hangzhou Municipal Natural Science Foundation(2024SZRZDC200001) （2024SZRZDC200001）
and Zhejiang Provincial Traditional Chinese Medicine Science and Technology Program(2023ZL362) （2023ZL362）
