中国药理学与毒理学杂志2025，Vol.39Issue(7)：538-549,12.DOI:10.3867/j.issn.1000-3002.2025.08291
嗜酸性粒细胞胃肠炎的治疗靶点及药物研究进展
Research progress in therapeutic targets and drugs for eosinophilic gastroenteritis
摘要
Abstract
Eosinophilic gastroenteritis(EG)is a rare disease characterized by abnormal infiltration of eosinophils(Eos)in gastrointestinal tissues.Due to the unclear pathogenesis of EG and the lack of effective therapeutic drugs,research on its novel mechanisms,targets and drugs is critical.This article starts by outlining the research progress in the pathogenesis of EG,involving IgE mediated typeⅠimmediate allergic reactions and T helper 2 cell(Th2)mediated delayed allergic reactions.Then,the related targets of EG are summarized,including Th2 cytokines and factors regulating Eos function,but there has been no breakthrough in the treatment of these targets.Finally,the therapeutic drugs for EG are reviewed,such as glucocorticoids,antiallergic drugs and biologics.The advantages and disadvantages of various drugs are also described.However,these drugs cannot meet the current demands of clinical treatment and there is an urgent need to develop novel therapeutic drugs.It is believed that multi-target therapy is an ideal treatment for EG,and that traditional Chinese medicine and natural products should be the priorities of research and development for EG therapeutic drugs in the future.This review is expected to provide new ideas for the clinical treatment strategies and drug development of EG.关键词
嗜酸性粒细胞胃肠炎/嗜酸性粒细胞/过敏反应/治疗靶点/治疗药物Key words
gastroenteritis/eosinophils/allergic reaction/therapeutic targets/therapeutic drugs分类
医药卫生引用本文复制引用
张心怡,姜胤如,赵子源,王珑睿,孙闻婧,杜冠华,孔令雷..嗜酸性粒细胞胃肠炎的治疗靶点及药物研究进展[J].中国药理学与毒理学杂志,2025,39(7):538-549,12.基金项目
中国医学科学院医学与健康科技创新工程(2022-I2M-1-015) CAMS Innovation Fund for Medical Sciences(CIFMS)(2022-I2M-1-015) （2022-I2M-1-015）
