中国药理学与毒理学杂志2025，Vol.39Issue(7)：550-558,9.DOI:10.3867/j.issn.1000-3002.2025.08288
靶向丙酮酸激酶M2的抗炎机制研究进展
Research progress in anti-inflammatory mechanisms of targeting pyruvate kinase M2
摘要
Abstract
The inflammatory response is a natural defense mechanism of the body that occurs in response to infection or injury,serving as a critical starting point for the onset and progression of various diseases.Glycolysis,an essential pathway for energy production within the body,plays a pivotal role in both the initiation and advancement of the inflammatory response.Pyruvate kinase M2(PKM2),recog-nized as a key rate-limiting enzyme in glycolysis,not only contributes to the inflammatory process by mediating glycolysis and lactylation modifications through such mechanisms as nuclear translocation and dimer formation,but also regulates the inflammatory response by modulating immune responses in B cells,T cells,macrophages,and neutrophils.This review aims to summarize the mechanisms involved in targeting PKM2 to suppress inflammation,providing new insights into the prevention and treatment of inflammatory reactions.关键词
炎症反应/丙酮酸激酶M2/糖酵解/乳酸化修饰/巨噬细胞Key words
inflammatory response/pyruvate kinase M2/glycolysis/lactylation/macrophage分类
医药卫生引用本文复制引用
张萌萌,申亮亮,曲璇..靶向丙酮酸激酶M2的抗炎机制研究进展[J].中国药理学与毒理学杂志,2025,39(7):550-558,9.基金项目
陕西省自然科学基础研究计划面上项目(2024JC-YBMS-720) （2024JC-YBMS-720）
陕西省自然科学基础研究计划面上项目(2023-JC-QN-0850) General Project of Shaanxi Natural Science Basic Research Plan(2024JC-YBMS-720) （2023-JC-QN-0850）
and General Project of Shaanxi Natural Science Basic Research Plan(2023-JC-QN-0850) （2023-JC-QN-0850）
