摘要
Abstract
Objective:To analyze the predictive value of combined detection of serum neutrophil-to-lymphocyte ratio(NLR),tumor necrosis factor-α(TNF-α),and D-dimer(D-D)levels for the clinical prognosis of patients with chronic obstructive pulmonary disease(Abbreviation:"COPD.").Methods:Two hundred patients with COPD admitted to our hospital from January 2022 to February 2024 were selected as the study subjects,and those who had health checkups in the same period were selected as the control group(n=200)and were divided into patients with good(n=163)and poor(n=37)prognosis according to their prognostic survival during hospitaliza-tion.The clinical general data and serum NLR,TNF-α and D-D levels of the 2 groups were compared.The clinical treatment methods and complications were compared in patients with different prognoses.Logistic regression analysis of factors affecting the poor prognosis of pa-tients with chronic obstructive pulmonary disease.The predictive value of serum NLR,TNF-α and D-D levels for poor prognosis was ana-lyzed.Results:The levels of serum NLR,TNF-α,and D-D in the study group were significantly higher than those in the control group(P＜0.05).The levels of NLR,TNF-α,and D-D in patients with poor prognosis were higher than those in patients with good prognosis(P＜0.05).The proportion of patients with good prognosis who received mechanical ventilation therapy and pulmonary heart disease was significantly lower than that of patients with poor prognosis(P＜0.05).Logistic regression analysis showed that mechanical ventilation,pulmonary heart disease,and high levels of serum NLR,TNF-α,and D-D were risk factors for poor patient prognosis(P＜0.05).The combined prediction of poor prognosis for patients with high serum NLR,TNF-α,and D-D levels at admission had an efficacy of 0.815,with the best sensitivity and specificity of 81.08％and 80.37％,respectively.Conclusion:Changes in serum levels of NLR,TNF-α,and D-D in patients with COPD can serve as effective indicators for evaluating patient prognosis.Their high expression is a risk factor for poor prognosis in patients.Strengthening tracking and monitoring of these levels is beneficial for control of the disease,aiming to provide a more comprehensive and accurate method for evaluating COPD prognosis in clinical practice.关键词
慢性阻塞性肺疾病/预后/中性粒细胞/淋巴细胞比值(NLR)/肿瘤坏死因子-α(TNF-α)/D-二聚体(D-D)Key words
Chronic obstructive pulmonary disease/Prognosis/Neutrophil-to-lymphocyte ratio(NLR)/tumor necrosis factor-α(TNF-α)/D-dimer(D-D)分类
医药卫生
