中国医学科学院学报2025，Vol.47Issue(3)：402-407,6.DOI:10.3881/j.issn.1000-503X.16279
胃食管反流病与慢性阻塞性肺疾病发病风险的关系
Association Between Gastroesophageal Reflux Disease and the Risk of Incident Chronic Obstructive Pulmonary Disease
廖叶 1周云峰 2周晓瑞 1胡昕 3廖娟 4龙璐1
作者信息
- 1. 四川大学华西公共卫生学院/四川大学华西第四医院流行病与卫生统计学系,成都 610041
- 2. 四川大学华西公共卫生学院/四川大学华西第四医院胸外科,成都 610041
- 3. 成都高新区石羊社区卫生服务中心,成都 610041
- 4. 四川大学华西公共卫生学院/四川大学华西第四医院消化科,成都 610041
- 折叠
摘要
Abstract
Objective To investigate the association between gastroesophageal reflux disease(GERD)and the risk of incident chronic obstructive pulmonary disease(COPD)and explore potential effect modifiers in-fluencing this association.Methods Clinical data from 476 175 participants in the UK Biobank(2006-2010)were collected.A Cox proportional hazards model was used to assess the relationship between GERD and the risk of incident COPD.Subgroup analyses were conducted to examine potential modifiers of the primary find-ings.Results A total of 11 587(2.43％)new COPD cases were diagnosed.The Cox proportional hazards model revealed that GERD was associated with an increased risk of incident COPD(HR=1.59,95％CI=1.46-1.74,P＜0.001).GERD was linked to a higher risk of incident COPD in individuals aged＜60 years(P＜0.001)and non-smokers(P=0.011).No association was observed between GERD and the risk of incident COPD in current smokers with a daily cigarette consumption＜10 cigarettes(P=0.261).Conclusion GERD may increase the risk of incident COPD.关键词
胃食管反流病/慢性阻塞性肺疾病/前瞻性研究Key words
gastroesophageal reflux disease/chronic obstructive pulmonary disease/prospective study分类
医药卫生引用本文复制引用
廖叶,周云峰,周晓瑞,胡昕,廖娟,龙璐..胃食管反流病与慢性阻塞性肺疾病发病风险的关系[J].中国医学科学院学报,2025,47(3):402-407,6.
