中国医药科学2025，Vol.15Issue(13)：4-8,142,6.DOI:10.20116/j.issn2095-0616.2025.13.01
基于SEER数据库的宫颈鳞癌预后预测模型构建及分析
Construction and analysis of a prognostic prediction model for cervical squamous cell carcinoma based on the SEER database
摘要
Abstract
Objective To explore the impact of clinicopathological characteristics on the prognosis of cervical squamous cell carcinoma(CSCC)patients and to construct a prognostic prediction model.Methods A retrospective analysis was conducted on data from 5189 CSCC patients in the SEER database from January 1,2010,to December 31,2020.Univariate and multivariate Cox proportional hazards regression models were used to identify potential factors influencing overall survival(OS).Kaplan-Meier survival analysis was performed for stratified analysis,and a prognostic prediction model based on risk factors was constructed.The model's performance was evaluated using ROC curves,calibration curves,and decision curve analysis.Results Age,N stage,M stage,AJCC stage,chemotherapy,tumor size,and number of lymph nodes examined were identified as independent prognostic factors for cervical squamous cell carcinoma.Patients aged≥65 years,with lymph node metastasis,distant metastasis,tumor diameter>2 cm,or without lymph node examination had higher mortality risks(P<0.05).The model demonstrated good predictive accuracy and clinical applicability.Conclusion The prognostic model constructed based on SEER data highlights the impact of key prognostic factors on survival and provides a basis for individualized treatment plans for patients with cervical squamous cell carcinoma.关键词
宫颈鳞癌/预测模型/SEER数据库/预后/列线图Key words
Cervical squamous cell carcinoma/Prediction model/SEER database/Prognosis/Nomogram分类
医药卫生引用本文复制引用
努尔比亚·依比布拉,路鹏霏,张华..基于SEER数据库的宫颈鳞癌预后预测模型构建及分析[J].中国医药科学,2025,15(13):4-8,142,6.基金项目
省部共建中亚高发病成因与防治国家重点实验室开放课题项目(SKL-HIDCA-2020-GJ5). （SKL-HIDCA-2020-GJ5）
