中华中医药杂志2025，Vol.40Issue(5)：2123-2128,6.
不同机体状态即时揿针针刺"四关穴"的脑功能活动响应异同研究
Differential and common brain responses to immediate intradermal acupuncture at 'Siguan' acupoints under different functional states
摘要
Abstract
Objective:To compare the central response characteristics of individuals under different functional states during immediate intradermal acupuncture at 'Siguan' acupoints.Methods:Twenty patients with tension-type headache(TTH)and forty healthy controls(HCs)underwent resting-state functional magnetic resonance imaging(rs-fMRI)scans and fMRI scans with immediate intradermal acupuncture at 'Siguan' acupoints.The regions with similar and different changes in brain functional activities during immediate intradermal acupuncture between TTH patients and HCs were detected based on the fractional amplitude of low-frequency fluctuation(fALFF)analysis method.Results:TTH patients showed a targeted downregulation of the fALFF value in the right precentral gyrus and had a more extensive modulation on the limbic-paralimbic system during instant intradermal acupuncture at 'Siguan' acupoints.Both groups exhibited an increase in the fALFF values in the superior frontal gyrus,the middle frontal gyrus,and a decrease in the lingual gyrus,the middle/inferior occipital gyrus,precentral/postcentral gyrus during acupuncture procedure.Conclusion:The widespread changes of functional activities in brain regions related to pain regulation and the limbic-paralimbic system may represent the specificity of central responses to needling the 'Siguan' acupoints in TTH state.And the modification of functional activity in the cognitive,visual and sensorimotor cortexes is a common brain response characteristic observed in both TTH patients and HCs during instant intradermal acupuncture at 'Siguan' acupoints.关键词
机体状态/四关穴/中枢响应/紧张型头痛/即时针刺/脑功能/功能性磁共振成像Key words
Functional states/Siguan acupoints/Central response/Tension-type headache(TTH)/Immediate acupuncture/Brain function/Functional magnetic resonance imaging(fMRI)引用本文复制引用
张心悦,周俊,蒋楠楠,黎信陵,胡胜婕,李政杰,曾芳..不同机体状态即时揿针针刺"四关穴"的脑功能活动响应异同研究[J].中华中医药杂志,2025,40(5):2123-2128,6.基金项目
国家自然科学基金杰出青年科学基金项目(No.82225050),国家自然科学基金面上项目(No.82474657,No.81973958),四川省科技厅杰出青年科学基金项目(No.2025NSFJQ0056),四川省科技厅自然科学基金项目(No.2025ZNSFSC1845) （No.82225050）
