中国真菌学杂志2025，Vol.20Issue(3)：289-293,5.
肱骨近端隐球菌感染1例报道并文献复习
Cryptococcal osteomyelitisof the proximal humerus:A case report and literature review
叶永贤 1赵佳丽 2洪海森 1诸灵祺 1林金河 1沙漠1
作者信息
- 1. 第九○九医院(厦门大学附属东南医院)骨科,漳州 363000
- 2. 福建医科大学附属漳州市医院药学部,漳州 363000
- 折叠
摘要
Abstract
A clinical case of cryptococcal osteomyelitis of the proximal humerus confirmed by histopathology and next-gen-eration sequencing was reported,and the literature was reviewed and analyzed based on relevant domestic and international reports.A 31-year-old woman with a history of type 1 diabetes showed pain and discomfort in the left shoulder joint for more than 2 months.Computed tomography(CT)revealed bone destruction of the left humeral head,and magnetic resonance im-aging(MRI)indicated aseptic necrosis of the same area.The surgical lesion was removed and the pathological examination revealed a granulomatous lesion of the left humerus.It was diagnosed as fungal infection via immunohistochemistry and spe-cial staining,and Cryptococcus was foundas pathogen.The second-generation sequencing showed that Cryptococcus neofor-mans was the main suspected pathogen.Fluconazole therapy was given.After 8 months of follow-up,the scope of the lesion was significantly reduced,and the infection was well controlled.Isolatedcryptococcal infection of the skeletal system wasrare and couldbe easily misdiagnosed as tumors,tuberculosis orother diseases.The diagnosis mainly depends on pathological ex-amination and microbial culture.As an emerging detection technology,next-generation sequencing can be used as an impor-tant basis for diagnosis.The prognosis is good after surgical lesion removal combined with oral antifungal therapy.关键词
隐球菌/肱骨近端/二代测序/免疫组化/微生物培养Key words
Cryptococcus/proximal humerus/next-generation sequencing/immunohistochemistry/microbial culture分类
医药卫生引用本文复制引用
叶永贤,赵佳丽,洪海森,诸灵祺,林金河,沙漠..肱骨近端隐球菌感染1例报道并文献复习[J].中国真菌学杂志,2025,20(3):289-293,5.
