中国肿瘤生物治疗杂志2025，Vol.32Issue(7)：673-680,8.DOI:10.3872/j.issn.1007-385x.2025.07.001
肿瘤免疫治疗的新视角:T细胞代谢调控
A new perspective on tumor immunotherapy:metabolic regulation of T cells
摘要
Abstract
Despite the remarkable clinical efficacy achieved by immune checkpoint blockade(ICB)and adoptive T cell therapy,the majority of patients with solid tumors still fail to achieve long-term responses to immunotherapy.One important reason is the complex metabolic patterns and inhibitory signals within the tumor microenvironment(TME),which induce metabolic reprogramming in immune cells and thereby impair their anti-tumor efficacy.This review summarizes the metabolic preferences of CD8+T cells across various differentiation states,explores the metabolic changes that occur during their interaction with tumor cells and the TME,and discusses how these metabolic changes affect differentiation,function,and stemness of CD8+T cells.Additionally,strategies that target metabolic molecules or pathways are highlighted to enhance the antitumor ability of CD8+T cells,thereby improving the efficacy of chimeric antigen receptor gene-modified T lymphocyte(CAR-T cell)immunotherapy and ICB therapy.关键词
CD8+T细胞/代谢重编程/肿瘤微环境/CAR-T细胞Key words
CD8+T cell/metabolic reprogramming/tumor microenvironment(TME)/chimeric antigen receptor gene-modified T lymphocyte(CAR-T cell)分类
医药卫生引用本文复制引用
李华域,李春阳,马春红..肿瘤免疫治疗的新视角:T细胞代谢调控[J].中国肿瘤生物治疗杂志,2025,32(7):673-680,8.基金项目
癌症、心脑血管、呼吸和代谢性疾病防治研究国家科技重大专项(No.2024ZD0519900) （No.2024ZD0519900）
国家自然科学基金(No.82230056,No.82471870) （No.82230056,No.82471870）
国家生物药技术创新中心"揭榜挂帅"技术攻关项目(No.NCTIB2023XB02006) （No.NCTIB2023XB02006）
