中国中西医结合影像学杂志2025，Vol.23Issue(4)：467-472,6.DOI:10.3969/j.issn.1672-0512.2025.04.012
双源CT双能量成像联合影像组学在鉴别甲状腺良恶性结节中的应用价值
Application value of dual-source dual-energy CT combined with radiomics in differential diagnosis of benign and malignant thyroid nodules
摘要
Abstract
Objective:To investigate the value of dual-source dual-energy CT combined with radiomics in differential diagnosis of benign and malignant thyroid nodules.Methods:A total of 118 patients with 128 thyroid nodules confirmed by pathology were retrospectively analyzed,inlcuding 60 benign nodules and 68 malignant nodules.All nodules were randomly divided into a training set(85 nodules)and a validation set(43 nodules).The clinical and imaging features and dual-energy quantitative parameters were collected.Clinical independent predictors were screened and the clinical model was constructed through multivariate logistic regression analysis.The radiomics features of non-enhanced and enhanced images were extracted,and the LASSO algorithm was used to select the optimal features to construct the radiomics model.The clinical independent predictors and radiomics features were selected to construct the clinical-radiomics model and a nomogram was drawn.ROC curve was used to evaluated the diagnosis efficiency,DeLong test was used to compare the AUC values of different models,and calibration curve and decision curve were uesd to evaluate the calibration of the model and its clinical benefits.Results:Nodule calcification,aspect ratio and normalized iodine concentration(NIC)in the arterial phase were independent predictors for malignant thyroid nodules and were used to construct the clinical model.The AUC values of the clinical model in the training set and validation set were 0.860 and 0.848,those of the radiomics model were 0.937 and 0.918,and those of the clinical-radiomics model were 0.967 and 0.937,the highest.DeLong test showed that there was a significant difference between the clinical-radiomics model and the clinical model in the training set(P≤0.05).The calibration curve showed that the prediction results of the clinical-radiomics model were consistent with the actual results,and the decision curve analysis showed a high clinical benefit.Conclusion:The clinical-radiomics model in the preoperative identification of benign and malignant thyroid nodules have high clinical value.关键词
甲状腺结节/影像组学/碘浓度/体层摄影术,X线计算机Key words
Thyroid nodules/Radiomics/Iodine concentration/Tomography,X-ray computed引用本文复制引用
冯俏,岳志斌,孙樱函,全江海,程留慧..双源CT双能量成像联合影像组学在鉴别甲状腺良恶性结节中的应用价值[J].中国中西医结合影像学杂志,2025,23(4):467-472,6.基金项目
河南省卫生健康委国家中医临床研究基地科研专项(2021JDZY100). （2021JDZY100）
