摘要
Abstract
Objective:To explore the effects of acetylcysteine combined with clarithromycin on symptoms,pulmonary ventilation,and Th1/Th2 cytokine imbalance in children with Mycoplasma pneumoniae pneumonia(MPP).Methods:A total of 114 MPP children admitted to a hospital from April 2021 to April 2024 were randomly assigned to the control group(n=57,clarithromycin monotherapy)or the observation group(n=57,acetylcysteine plus clarithromycin)using a random number table.Lung ventilation functions[forced vital capacity(FVC),maximum voluntary ventilation(MVV),maximal mid-expiratory flow(MMEF),forced expiratory volume in 1 second(FEV1)/FVC ratio]and Th1/Th2 cytokines[interferon-γ(INF-γ),tumor necrosis factor-α(TNF-α),interleukin-4(IL-4),IL-6,IL-10]were measured before and after treatment.Clinical efficacy,symptom improvement,and adverse drug reactions were compared between groups.Results:After treatment,serum levels of TNF-α,IL-4,IL-6,IL-10,and INF-γ decreased significantly in both groups(P＜0.05),with more pronounced reductions in the observation group(P＜0.05).Conversely,FVC,MVV,MMEF,and FEV1/FVC increased significantly in both groups(P＜0.05),with higher values in the observation group(P＜0.05).The observation group showed shorter resolution times for fever,cough,lung rales,and pulmonary shadows(P＜0.05).The total effective rate was 94.74％in the observation group,significantly higher than 80.70％in the control group(P＜0.05).No significant difference in adverse drug reaction rates was found between groups(P＞0.05).Conclusion:Acetylcysteine combined with clarithromycin effectively alleviates symptoms,improves pulmonary ventilation,and enhances clinical efficacy in children with MPP,without increasing the risk of adverse reactions.关键词
肺炎支原体肺炎/乙酰半胱氨酸/克拉霉素/肺通气/Th1/Th2细胞因子Key words
Mycoplasma pneumoniae pneumonia/acetylcysteine/clarithromycin/pulmonary ventilation/Th1/Th2 cytokines分类
医药卫生
