中国合理用药探索2025，Vol.22Issue(6)：29-34,6.DOI:10.3969/j.issn.2096-3327.2025.06.006
强化剂量的瑞舒伐他汀联合依洛尤单抗对急性心肌梗死患者经皮冠脉介入术后SYNTAX评分及临床结局的影响
Influence of Intensive Dose of Rosuvastatin Combined with Evolocumab on SYNTAX Score and Clinical Outcomes in Patients with Acute Myocardial Infarction After Percutaneous Coronary Intervention
摘要
Abstract
Objective:To explore the efficacy of intensive-dose rosuvastatin combined with evolocumab in patients with acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI),and to analyze its impact on synergy between pci with taxus and cardiac surgery score(SYNTAX score)and clinical outcomes.Methods:A total of 106 AMI patients who underwent PCI in our hospital from January 2022 to January 2024 were enrolled and randomly divided into the observation group(n=53)and control group(n=53)using a random number table.The control group received conventional-dose rosuvastatin(10 mg/d)combined with evolocumab,while the observation group received intensive-dose rosuvastatin(20 mg/d)combined with evolocumab.All patients were followed up for 10 months to evaluate the clinical effects.Results:After treatment,levels of low-density lipoprotein cholesterol(LDL-C),triglycerides,neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),SYNTAX score,and coronary microvascular flow frame count significantly decreased in both groups(all P＜0.05),with more pronounced reductions in the observation group(all P＜0.05).Left ventricular global longitudinal strain,global work efficiency,and global useful work were significantly increased in both groups(all P＜0.05),and the observation group exhibited higher values(all P＜0.05).The total incidence of adverse reactions was lower in the observation group(7.55％)than in the control group(22.64％,P＜0.05).Logistic regression analysis revealed that post-treatment LDL-C and NLR levels were independent risk factors for adverse events(all P＜0.05).Conclusion:Intensive-dose rosuvastatin combined with evolocumab can more effectively improve lipid metabolism,inflammatory status,coronary circulation,and left ventricular remodeling in AMI patients after PCI,and reduce the risk of postoperative adverse events.关键词
急性心肌梗死/瑞舒伐他汀/依洛尤单抗/经皮冠脉介入术/冠脉造影评分Key words
acute myocardial infarction/rosuvastatin/evolocumab/percutaneous coronary intervention/SYNTAX score分类
医药卫生引用本文复制引用
张培勇,郭永龙,王晓敏,李红军..强化剂量的瑞舒伐他汀联合依洛尤单抗对急性心肌梗死患者经皮冠脉介入术后SYNTAX评分及临床结局的影响[J].中国合理用药探索,2025,22(6):29-34,6.基金项目
河南省2022年医学科技攻关计划联合共建项目(LHGJ20220588) （LHGJ20220588）
