中国合理用药探索2025，Vol.22Issue(6)：42-49,8.DOI:10.3969/j.issn.2096-3327.2025.06.008
普罗布考联合阿托伐他汀钙对急性脑梗死患者脑血管储备功能、认知功能、神经损伤因子的影响
Effects of Probucol Combined with Atorvastatin Calcium on Cerebrovascular Reserve Capacity,Cognitive Function and Neuroinjury Biomarkers in Patients with Acute Cerebral Infarction
摘要
Abstract
Objective:To investigate the effects of probucol combined with atorvastatin calcium on cerebrovascular reserve capacity,cognitive function and neuroinjury biomarkers in patients with acute cerebral infarction(ACI).Methods:A total of 94 ACI patients admitted to a certain hospital from July 2021 to June 2024 were enrolled and divided into the control group and the observation group using random number table method,with 47 patients in each group.Both groups received standard care,including intravenous thrombolysis,antiplatelet therapy,etc.The control group was treated with atorvastatin calcium tablets,while the observation group received probucol tablets on the basis of the treatment in the control group.Both groups were treated for 6 months.The lipid profiles[total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)],cerebrovascular reserve capacity indicators[middle cerebral artery pulsatility index(MCAPI),middle cerebral artery(MCA)blood flow velocity,cerebrovascular reserve(CVR)],neuroinjury biomarkers[soluble lectin-like oxidized low-density lipoprotein receptor-1(sLOX-1),endothelial cell-specific molecule-1(ESM-1),vasohibin-1(VASH-1)],cognitive function[Montreal cognitive assessment(MoCA)score],clinical efficacy,post-treatment vascular restenosis and adverse reactions were compared between the two groups.Results:After treatment,TC,TG,LDL-C,MCAPI,sLOX-1,ESM-1 and VASH-1 were decreased in both groups(P＜0.05),with more pronounced reductions in the observation group compared to the control group(P＜0.05).HDL-C,MCA blood flow velocity and CVR were increased in both groups(P＜0.05),with the observation group demonstrating significantly higher values(P＜0.05).Both subscale and total scores of MoCA were increased in both groups(P＜0.05),with the observation group showing higher scores than the control group(P＜0.05).The overall clinical response rate was in the observation group(91.49％)higher than that in the control group(70.21％,P＜0.05).No vascular restenosis were observed in either group post-treatment.No statistically significant difference in the overall incidence of adverse reactions between the two groups(P＞0.05).Conclusion:Probucol combined with atorvastatin calcium exhibits superior clinical efficacy in treating ACI patients,effectively improving cerebrovascular reserve capacity and cognitive function,alleviating neuro-functional impairment,reducing neuroinjury biomarker levels,and without increasing the risk of adverse reactions.关键词
普罗布考/急性脑梗死/脑血管储备功能/认知功能/神经损伤因子Key words
probucol/acute cerebral infarction/cerebrovascular reserve capacity/cognitive function/neuroinjury biomarker分类
医药卫生引用本文复制引用
赵文栋,张清峡,柴晓燕,赵远,张毅,刘艳霞..普罗布考联合阿托伐他汀钙对急性脑梗死患者脑血管储备功能、认知功能、神经损伤因子的影响[J].中国合理用药探索,2025,22(6):42-49,8.基金项目
河南省医学科技攻关计划项目(LHGJ20230500) （LHGJ20230500）
