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脑血管病的多组学研究

张杰 李昊 程丝

中国卒中杂志2025,Vol.20Issue(6):657-662,6.
中国卒中杂志2025,Vol.20Issue(6):657-662,6.DOI:10.3969/j.issn.1673-5765.2025.06.001

脑血管病的多组学研究

Multi-omics Research in Cerebrovascular Disease

张杰 1李昊 2程丝2

作者信息

  • 1. 北京 100070 首都医科大学附属北京天坛医院,国家神经系统疾病临床医学研究中心,卒中多组学创新中心||脑血管病药械研发北京市重点实验室
  • 2. 北京 100070 首都医科大学附属北京天坛医院,国家神经系统疾病临床医学研究中心,卒中多组学创新中心||脑血管病药械研发北京市重点实验室||首都医科大学卒中精准临床诊疗与研究中心
  • 折叠

摘要

Abstract

Currently,cerebrovascular disease still faces challenges in elucidating mechanisms,constructing specialized cohorts,and developing new drugs.The advancement of multi-omics has provided a driving force for understanding the complex pathophysiological regulatory mechanisms,optimizing disease classification and diagnosis,enhancing prognosis prediction capabilities,and advancing the new drug development process.China has established the STROMICS database,a multi-omics and multimodal database of cerebrovascular disease at the ten-thousand-person level.China will further develop a more comprehensive multi-omics cohort for cerebrovascular disease and advance multi-omics research through interdisciplinary approaches such as Mendelian randomization.This will provide methods to deepen the understanding of the regulatory mechanisms underlying cerebrovascular disease and to facilitate new drug development.

关键词

脑血管病/卒中/多组学

Key words

Cerebrovascular disease/Stroke/Multi-omics

分类

医药卫生

引用本文复制引用

张杰,李昊,程丝..脑血管病的多组学研究[J].中国卒中杂志,2025,20(6):657-662,6.

基金项目

国家自然科学基金(82471304)国家重点研发计划(2022YFE0209600)中国科协青年人才托举工程(2023QNRC001) (82471304)

中国卒中杂志

OA北大核心

1673-5765

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