转化医学杂志2025，Vol.14Issue(6)：47-51,5.DOI:10.3639/j.issn.2095-3097.2025.06.009
脂蛋白(a)联合CatLet©评分对急诊PCI术后AMI患者主要不良心脑血管事件的预测价值
Predictive Value of Lipoprotein(a)Combined with the CatLet© Coronary Score for MACCE in AMI Patients Undergoing Emergency Percutaneous Coronary Intervention
摘要
Abstract
Objective To investigate the predictive value of lipoprotein(a)[LP(a)]combined with the CatLet© coro-nary score for major adverse cardiovascular and cerebrovascular events(MACCE)in acute myocardial infarction(AMI)patients treated with emergency percutaneous coronary intervention(PCI).Methods This retrospective study enrolled 307 consecutive acute myocardial infarction(AMI)patients who successfully underwent emergency PCI at the Department of Cardiology,Bozhou Hospital Affiliated to Anhui Medical University,from January 2020 to May 2022.Based on 1-year follow-up outcomes,patients were categorized into the MACCE group(n=78)and the non-MACCE group(n=229).Baseline lipoprotein(a)[LP(a)]levels were measured,and both CatLet© and Gensini scores were calculated for all participants.Multivariate logistic regression analysis was performed to identify independent predictors of MACCE,while receiver operating characteristic(ROC)curve analysis was employed to evaluate the predictive performance of LP(a),the CatLet© score,and their combination for MACCE.Results The MACCE group exhibited significantly higher LP(a)levels and CatLet© scores compared to the non-MACCE group(P<0.05).Mul-tivariate analysis identified both LP(a)(OR=2.293,95%CI:1.523-3.462,P=0.018)and the CatLet© score(OR=1.093,95%CI:1.032-1.164,P=0.003)as independent predictors of MACCE.ROC curve analysis demonstrated that the combination of LP(a)(-cut-off:169.68 pg/mL)and the CatLet© score(cut-off:18.6)significantly enhanced predictive performance(AUC=0.862),with a sensitivity of 88.46%and specificity of 83.33%.Delong test confirmed the superiority of the combined model over individual predictors(P=0.0089,Z=2.64 vs LP(a);P=0.034,Z=2.12 vs CatLet© score).Conclusion The combination of LP(a)and the CatLet© score provides a more accurate prediction of MACCE risk in AMI patients following emergency PCI compared to either predictor alone.This integrated approach offers a novel clinical strategy for prognostic evaluation.关键词
脂蛋白(a)/CatLet©/冠状动脉评分/急性心肌梗死/主要心脑血管不良事件Key words
Lipoprotein(a)/CatLet©/Coronary angiography score/Acute myocardial infarction/Major adverse cardio-vascular and cerebrovascular events分类
医药卫生引用本文复制引用
涂胜,王梦茹,户富栋,王莹,卜令同,江荣炎..脂蛋白(a)联合CatLet©评分对急诊PCI术后AMI患者主要不良心脑血管事件的预测价值[J].转化医学杂志,2025,14(6):47-51,5.基金项目
河南省医学科技攻关计划,省部共建重点项目(SBGJ202102153) （SBGJ202102153）
安徽高校自然科学研究重点项目(KJ2020A0336) （KJ2020A0336）
安徽省亳州市重点研发计划项目(bzzc2024004) （bzzc2024004）
