神经药理学报2025，Vol.15Issue(2)：47-53,7.DOI:10.3969/j.issn.2095-1396.2025.02.009
脑缺血再灌注损伤新治疗靶点:线粒体通透性转换孔
Cerebral Ischemia-Reperfusion Injury of New Therapeutic Targets:Mitochondrial Permeability Transition Pore
尚容正 1张可鑫 1张丹参1
作者信息
- 1. 河北科技大学化学与制药工程学院,石家庄,050018,中国
- 折叠
摘要
Abstract
Cerebral ischemia-reperfusion injury is a pathological process in which the structure and function of nerve cells are further impaired after the blood supply to ischemic stroke is restored.As the most important and sensitive organelle of the body,mitochondria play a vital role in cell survival,and among the many potential mechanisms of mitochondrial dysfunction,the excessive opening of mitochondrial permeability transition pore is one of the mechanisms that has attracted much attention in recent years.This article systematically reviews the research status of mPTP and I/R,in order to provide new ideas for the clinical treatment of cerebral ischemia and reperfusion injury,which can lead to abnormal opening of mPTP and trigger cell dysfunction.关键词
线粒体通透性转换孔/脑缺血再灌注损伤Key words
mitochondrial permeability transition pore/cerebral ischemia-reperfusion injury分类
医药卫生引用本文复制引用
尚容正,张可鑫,张丹参..脑缺血再灌注损伤新治疗靶点:线粒体通透性转换孔[J].神经药理学报,2025,15(2):47-53,7.
