神经药理学报2025，Vol.15Issue(2)：54-60,7.DOI:10.3969/j.issn.2095-1396.2025.02.010
线粒体自噬在阿尔茨海默病中的作用及机制研究进展
Advances in the Role and Mechanisms of Mitophagy in Alzheimer's Disease
摘要
Abstract
The pathogenesis of Alzheimer's disease(AD)has been extensively studied,revealing that impaired mitophagy is one of the critical factors contributing to AD development.In AD,excessive production of reactive oxygen species(ROS)and alterations in mitochondrial membrane potential lead to mitochondrial dysfunction,structural damage,and the accumulation of impaired mitochondria due to defective mitophagy,thereby exacerbating the progression of AD.This review summarizes the relationship between mitophagy and AD,encompassing the hallmarks of AD,the fundamental mechanisms of mitophagy,and the roles of key signaling pathways such as PINK1-Parkin,FUNDC1,and BNIP3/NIX in regulating mitophagy.Additionally,it explores the interactions between mitophagy and pathological hallmarks of AD,including β-amyloid(Aβ)peptides and Tau proteins.By systematically analyzing the interplay between mitophagy and AD,this article aims to provide new insights for early diagnosis and targeted therapy of AD through the enhancement of mitophagy,potentially offering a promising therapeutic strategy for mitigating AD pathology.关键词
线粒体自噬/阿尔茨海默病/信号通路Key words
mitophagy/Alzheimer's disease/signaling pathway分类
医药卫生引用本文复制引用
马梦凡,赵梓妤,张鑫,沈丽霞..线粒体自噬在阿尔茨海默病中的作用及机制研究进展[J].神经药理学报,2025,15(2):54-60,7.基金项目
河北省研究生创新资助项目(No.CXZZSS2025122),河北省高等学校科学技术研究项目(No.ZD2020136) （No.CXZZSS2025122）
