浙江医学2025，Vol.47Issue(13)：1389-1393,5.DOI:10.12056/j.issn.1006-2785.2025.47.13.2024-365
CT放射组学评分对临床Ⅰ期肺癌患者发生肺泡腔隙扩散的预测价值
Value of CT radiomics score in predicting spread through air spaces in clinical stage Ⅰ lung cancer
摘要
Abstract
Objective To explore the value of CT radiomics score in predicting spread through air spaces(STAS)in clinical stage Ⅰ lung cancer.Methods A retrospective analysis was conducted on 378 patients pathologically diagnosed with lung cancer in the Affiliated Jinhua Hospital,Zhejiang University School of Medicine from March 2020 to March 2023.Patients were divided into a positive group(n=111)and a negative group(n=267)according to postoperative pathological examination results.Clinical data of the two groups were compared,and multivariate logistic regression analysis was used to screen the factors influencing STAS occurrence in stage Ⅰ lung cancer.ROC curve was drawn to analyze the predictive efficacy of CT radiomics score for STAS in stage Ⅰ lung cancer.Results The age,maximum diameter of nodule,volume of the nodule,consolidation to tumour ratio(CTR),T stage,pathological pattern,CT radiomics score,recurrence rate,proportion of nodular signs includirg lobulation,spiculation,pleural indentation and bronchial inflation between the two groups were all significantly different(P＜0.05).The maximum diameter of nodule(OR=1.652),CTR(OR=1.287),CT radiomics score(OR=3.010),and T2a stage(OR=2.713)were independent influencing factors for developing STAS in patients with stage Ⅰ lung cancer(all P＜0.05).The AUC of CT radiomics score for predicting STAS of stage Ⅰ lung cancer was 0.856(95％CI:0.801-0.899),with a sensitivity of 0.776 and a specificity of 0.849.Conclusion STAS in stage Ⅰ lung cancer is related to early recurrence,and CT radiomics score can well predict the risk of STAS.关键词
肺癌/肺泡腔隙扩散/放射组学/实性成分占比/复发Key words
Lung cancer/Spread through air spaces/Radiomics/Consolidation to tumour ratio/Recurrence引用本文复制引用
黄侃,许博,楼洋..CT放射组学评分对临床Ⅰ期肺癌患者发生肺泡腔隙扩散的预测价值[J].浙江医学,2025,47(13):1389-1393,5.基金项目
金华市科技研究计划项目(2020-3-040) （2020-3-040）
