肿瘤防治研究2025，Vol.52Issue(7)：533-538,6.DOI:10.3971/j.issn.1000-8578.2025.25.0241
TLR7/8激动剂联合放疗:肿瘤原位疫苗应用新模式探索
A Novel Application Paradigm for Tumor In-Situ Vaccination:Synergistic Effects of TLR7/8 Agonists and Radiotherapy
游晓琳 1闵丽梅 1刘宝瑞 1李茹恬1
作者信息
- 1. 210008 南京,南京大学医学院附属鼓楼医院肿瘤科
- 折叠
摘要
Abstract
Tumor immunotherapy has achieved breakthroughs in the treatm-ent of malignant tumors by activating the host immune system's antitumor response mechanism.Among various strategies,Toll-like receptor(TLR)agonists have garnered substantial attention due to their unique immunomodulatory capabilities.This work reviews the research progress on the combination of TLR agonists with radiotherapy in tumor immunotherapy,focusing on the clinical translational potential of intratumoral injection strategies.Clinical studies have shown that the in-situ injection of TLR agonists in combination with radiotherapy can effectively suppress primary and metastatic lesions by inducing immunogenic cell death,releasing tumor antigens,activating local immune responses,and triggering abscopal effects.Moreover,novel extended-release formula-tions and"endogenous vaccine"designs further enhance the safety and durability of treatment.Despite several challenges such as tumor microenvironment suppression and dose optimization,TLR agonists hold promise for the treatment of"cold"tumors lacking innate immunity through combinations with immune checkpoint inhibitors,nanodelivery technologies,and precise biomarker screening.关键词
肿瘤/TLR激动剂/原位注射/放射治疗/远隔效应Key words
Tumor/TLR agonist/Intratumoral injection/Radiotherapy/Abscopal effect分类
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游晓琳,闵丽梅,刘宝瑞,李茹恬..TLR7/8激动剂联合放疗:肿瘤原位疫苗应用新模式探索[J].肿瘤防治研究,2025,52(7):533-538,6.
