肿瘤防治研究2025，Vol.52Issue(7)：548-553,6.DOI:10.3971/j.issn.1000-8578.2025.24.1291
河南省安阳市文峰区某自然村居民牙齿脱落与食管癌风险前瞻性研究
Prospective Study on Tooth Loss and Risk of Esophageal Cancer Among Residents of A Natural Village in Wenfeng District,Anyang City,Henan Province
摘要
Abstract
Objective To investigate the relationship between tooth loss and the occurrence of esophageal cancer in a natural village in Wenfeng District,Anyang City,Henan Province.Methods A prospective cohort study was conducted to observe the occurrence of tooth loss and esophageal cancer among the asymptomatic residents of the natural village for 16 years from January 2008 to July 2024.Data were analyzed by chi-square test,binary log-istic regression,and restricted cubic spline.Results Among the total pop-ulation of 711 cases,136 cases were lost to follow-up and 575 cases were inc-luded in the final statistics,including 45 cases with esophageal cancer.Signifi-cant statistical difference was found between esophageal cancer patients with and without tooth loss(P<0.05).Log-istic regression analysis showed that tooth loss was associated with the occ-urrence of esophageal cancer(OR=3.977,95%CI:1.543-10.255).After the adjustment for confounders,tooth loss remained significantly associated with the occurrence of eso-phageal cancer(OR=3.038,95%CI:1.035-8.914).A nonlinear dose-response relationship was observed between the number of teeth lost and the incidence of esophageal cancer.When the number of teeth lost was less than 12,the risk of esophageal cancer increased with the number of teeth lost.When more than 12 teeth were lost,the risk of esophageal cancer decreased as the number of teeth lost increased.Conclusion Tooth loss is a risk factor for the occurrence of esophageal cancer in this natural village.When the number of teeth lost is less than 12,the risk of esophageal cancer increases with the number of teeth lost.关键词
危险因素/牙齿脱落/食管癌/队列研究Key words
Risk factor/Tooth loss/Esophageal cancer/Cohort study分类
医药卫生引用本文复制引用
王静静,付亚如,李贝,刘军清,雷玲玲,刘敏,鲍启德,王立东,徐瑞华,张艳芳,赵学科,张强,宋昕,魏梦霞,郭军芳,韩雪娜..河南省安阳市文峰区某自然村居民牙齿脱落与食管癌风险前瞻性研究[J].肿瘤防治研究,2025,52(7):548-553,6.基金项目
2025年国家科技重大专项(2024ZD0520900 （）
2024ZD0520906) （）
国家自然科学基金面上项目(81872032) （81872032）
河南省濮阳市重大科技专项(210122) National Science and Technology Major Project(2025)(Nos.2024ZD0520900,2024ZD0520906) （210122）
National Natural Science Foundation of China Project(No.81872032) （No.81872032）
Major Science and Technology Project of Puyang City,Henan Province(No.210122) （No.210122）
