肿瘤防治研究2025，Vol.52Issue(7)：578-584,7.DOI:10.3971/j.issn.1000-8578.2025.24.1326
装载人参皂苷Rh2的外泌体对肝癌细胞生长的抑制作用
Inhibitory Effect of Exosomes Loaded with Ginsenoside Rh2 on Growth of Hepatocellular Carcinoma Cells
摘要
Abstract
Objective To explore the effects of exosomes loaded with ginsenoside Rh2 on the biological functions of hepatocellular carcinoma cells.Methods Both Huh7 and PLC/PRF/5 cell were equally divided into control group,exosome group(Exos group),drug group(G-Rh2 group),and exosomes-loaded-with-ginsenoside Rh2 group(Exos@G-Rh2 group).The effects of each group on the viability,clonogenic ability,migration ability,invasion ability,and apoptotic level of hepatocellular carcinoma cells were detected through CCK-8 assay,colony formation assay,cell scratch assay,Transwell assay,and flow cytometry.Results Comp-ared with the control group,the Exos@G-Rh2 group and G-Rh2 group showed significantly decreased cell viability,clonogenic ability,and migration and invasion capabilities,along with a markedly increased cell apoptosis rate(P<0.05).These changes were more pronounced in the Exos@G-Rh2 group than in the G-Rh2 group(P<0.05).Conclusion Exos@G-Rh2 can effectively inhibit the viability and clonogenic,migration,and invasion abilities of liver cancer cells and induce cell apoptosis.This effect is stronger than that of free G-Rh2 at the same concentration.关键词
肝癌/人参皂苷Rh2/外泌体Key words
Hepatocellular carcinoma/Ginsenoside rh2/Exosomes分类
医药卫生引用本文复制引用
李美乐,赵梓粤,金凯,谢裕安..装载人参皂苷Rh2的外泌体对肝癌细胞生长的抑制作用[J].肿瘤防治研究,2025,52(7):578-584,7.基金项目
Guangxi Key Laboratory Operation Subsidy Project(No.21-220-22) 广西重点实验室运行补助项目(21-220-22) （No.21-220-22）
