肿瘤防治研究2025，Vol.52Issue(7)：592-597,6.DOI:10.3971/j.issn.1000-8578.2025.24.1232
早期Luminal型乳腺癌患者辅助内分泌治疗不良反应与细胞因子的相关性
Correlation Between Adverse Reactions in Adjuvant Endocrine Therapy and Cytokines for Early-Stage Luminal-Type Breast Cancer Patients
摘要
Abstract
Objective To investigate the correlation between cytokines and the side effects of estrogen deprivation associated with adjuvant endocrine therapy in female patients with early luminal breast cancer.Methods A retrospective analysis was performed on the data of 70 patients with early-stage breast cancer who underwent both the Endocrine Symptom Scale(FACT-ES)assessment and cytokine testing at the Breast Clinic of the Department of Medical Oncology,Cancer Hospital,Chinese Academy of Medical Sciences,between April 2023 and June 2023.Results Binary logistic regression analysis revealed that breast cancer patients experiencing hot flashes had significantly higher serum levels of IL-5 compared with those without hot flashes(3.17 pg/ml vs.2.33 pg/ml,OR:1.307-7.66,P=0.011),and the patients experiencing irritability had significantly lower serum levels of IL-10(0.83 pg/ml vs.1.37 pg/ml)and INF-γ(19.91 pg/ml vs.35.93 pg/ml)compared with those without irritability(OR:0.855-0.983,P=0.015).Conclusion The elevated IL-5 may be associated with the occurrence of hot flashes,while lower levels of IL-10 and INF-γ may be linked to irritability in patients with early-stage Luminal breast cancer treated with adjuvant endocrine therapy.关键词
辅助内分泌治疗/乳腺癌/细胞因子/潮热/易激惹Key words
Adjuvant endocrine therapy/Breast cancer/Cytokines/Hot flashes/Irritability分类
医药卫生引用本文复制引用
郑晓娟,李逸群,马飞..早期Luminal型乳腺癌患者辅助内分泌治疗不良反应与细胞因子的相关性[J].肿瘤防治研究,2025,52(7):592-597,6.基金项目
Noncommunicable Chronic Disease-National Science and Technology Major Project(No.2023ZD0502200) （No.2023ZD0502200）
Cultivation Project of Medical Oncology Key Foundation of Cancer Hospital Chinese Academy of Medical Sciences(No.CICAMS-MOCP2022015,CICAMS-MOCP2022006) 国家科技四大慢病重大专项(2023ZD0502-200) （No.CICAMS-MOCP2022015,CICAMS-MOCP2022006）
中国医学科学院肿瘤医院内科重点学科基金培育基金(CICAMS-MOCP2022015,CICAMS-MOCP2022006) （CICAMS-MOCP2022015,CICAMS-MOCP2022006）
