中山大学学报（医学科学版）2025，Vol.46Issue(4)：558-567,10.
铜死亡与动脉粥样硬化的关系及其靶向治疗的研究进展
Research Progress on Relationship between Cuproptosis and Atherosclerosis and its Targeted Therapy
摘要
Abstract
Atherosclerosis(AS),a chronic and multifactorial vascular disease,involves diverse pathological processes including dyslipidemia,reactive oxygen species(ROS)generation,inflammatory cell infiltration,and local thrombosis.In recent years,cuproptosis,a novel form of copper-dependent programmed cell death,has attracted considerable attention.It is primarily triggered by the binding of excessive copper ions to lipoylated proteins,resulting in disruption of the tricarboxylic acid(TCA)cycle,damage to iron-sulfur cluster proteins,and consequent functional impairment of related enzymes and proteins,ultimately inducing cell death through multiple pathways.Previous studies have revealed the close association between cuproptosis and AS pathogenesis.Cuproptosis promotes ROS production,induces lipid peroxidation via the Fenton reaction,triggers inflammatory responses and disrupts mitochondrial TCA cycle,thereby compromising the functions of vascular cells(macrophages,endothelial cells,and smooth muscle cells),destabilizing plaques and exacerbating AS progression.Therefore,targeting cuproptosis may present a new direction for AS treatment and its complication prevention.Specifically,cuproptosis-related genes may serve as potential diagnostic biomarkers for AS,and pharmacological inhibition of cuproptosis has been shown to significantly modulate disease progression,highlighting the potential value of targeting cuproptosis in AS management.This review systematically summarizes the molecular mechanisms of copper metabolism and cuproptosis,their pathophysiological roles in AS,and recent advances in targeting cuproptosis for AS diagnosis and treatment,aiming to provide novel insights into clinical strategies for AS prevention and therapy.关键词
铜死亡/动脉粥样硬化/铜代谢/炎症/靶向治疗Key words
cuproptosis/atherosclerosis/copper metabolism/inflammation/targeted therapy分类
医药卫生引用本文复制引用
张子路,秦合伟..铜死亡与动脉粥样硬化的关系及其靶向治疗的研究进展[J].中山大学学报（医学科学版）,2025,46(4):558-567,10.基金项目
国家自然科学基金(82374551) （82374551）
河南省卫生健康中青年学科带头人项目(豫人卫[2024]3号) （豫人卫[2024]3号）
河南省高等学校重点科研项目(24B360003) （24B360003）
河南省中医学"双一流"创建科学研究专项课题(HSRP-DFCTCM-2023-3-27) （HSRP-DFCTCM-2023-3-27）
