中山大学学报（医学科学版）2025，Vol.46Issue(4)：574-582,9.
泛凋亡在缺血-再灌注损伤疾病中的研究进展
Research Progress on PANoptosis in Ischemia-reperfusion Injury Diseases
摘要
Abstract
PANoptosis,a newly characterized form of programmed cell death,exhibits hybrid molecular features of pyroptosis,apoptosis,and necroptosis,orchestrated by upstream PANoptosomes.This process is critically implicated in the pathophysiological progression of infectious and inflammatory disorders.Previously,these pathways of programmed cell death were considered mutually exclusive signaling systems.Previously advanced molecular interrogation has revealed intricate cross-regulatory networks among them.Researchers have formally defined this inter-pathway communication mechanism as PANoptosis.Emerging evidence implicates PANoptosis in diverse human pathologies,including infectious diseases,neurological disorders,and malignancies.Notably,PANoptosis has emerged as a critical modulator of ischemia-reperfusion injury(IRI)-associated pathologies,though its precise regulatory mechanisms remain incompletely delineated.A comprehensive understanding of the research advances in PANoptosis within IRI-related pathologies,coupled with the systematic elucidation of its regulatory mechanisms,holds transformative potential for therapeutic breakthroughs in disease management.As a feasible intervention target,PANoptosis has proven promising in studies and become a focus of intense research.This comprehensive review critically analyzes current knowledge on PANoptosis,including its definitions,molecular hallmarks,regulatory mechanisms,and pathophysiological correlations in IRI,to catalyze the development of transformative therapeutic strategies and pertinent medications for IRI management.关键词
泛凋亡/泛凋亡小体/缺血-再灌注损伤/细胞程序性死亡/综述Key words
PANoptosis/PANoptosome/ischemia-reperfusion injury/programmed cell death/review分类
医药卫生引用本文复制引用
高翔,冯博..泛凋亡在缺血-再灌注损伤疾病中的研究进展[J].中山大学学报（医学科学版）,2025,46(4):574-582,9.基金项目
2024年度河南省医学科技攻关计划联合共建项目(LHGJ20240663) （LHGJ20240663）
