中山大学学报（医学科学版）2025，Vol.46Issue(4)：583-597,15.
全生命周期ASD患者语言障碍相关潜在神经影像学标志物的研究进展
Research Progress on Potential Neuroimaging Biomarkers Associated with Language Impairments in ASD Patients Across the Life Stages
摘要
Abstract
Autism spectrum disorder(ASD)is a neurodevelopmental disorder characterized by early onset,high prev-alence,and typically lifelong impact.A significant body of empirical research has focused on language impairments,a hall-mark feature of ASD,aiming to identify its potential neuroimaging biomarkers via neuroimaging techniques.This paper systematically reviews international neuroimaging studies on language impairments in ASD over the past 15 years from a life stage perspective.It explores research progress on four potential neuroimaging biomarkers—structure/structural connectivity,function/functional connectivity,neural oscillations,and electroencephalogram(EEG)/magnetoencephalography(MEG)components—related to syllable perception,phonetic perception,lexical comprehension,sentence comprehension,discourse comprehension,lexical production,and overall language abilities in ASD patients across different life stages,including infancy,childhood,adolescence,middle age,and old age.By analyzing these biomarkers in detail across vari-ous age groups,the review not only provides a comprehensive theoretical framework and the latest trends from a neuroimag-ing perspective,deepening the understanding of the neural mechanisms underlying language impairments in ASD,but also offers a scientific basis for developing personalized intervention and treatment strategies.Furthermore,the integration of these neuroimaging biomarkers across different age stages with artificial intelligence technology holds promise for age-spe-cific screening,diagnosis,and prognostic evaluation,thereby improving the accuracy of diagnosis and prognosis.In sum-mary,this review provides valuable input for advancing research on ASD and its application in clinical practice.关键词
全生命周期/孤独症谱系障碍患者/语言障碍/神经影像学技术/潜在神经影像学标志物Key words
life stagse/autism spectrum disorder patients/language impairments/neuroimaging techniques/potential neuroimaging biomarkers分类
医药卫生引用本文复制引用
谭娅,姜孟..全生命周期ASD患者语言障碍相关潜在神经影像学标志物的研究进展[J].中山大学学报（医学科学版）,2025,46(4):583-597,15.基金项目
重庆市社会科学基金(2019YBYY131) （2019YBYY131）
重庆市研究生科研创新项目(CYB22252) （CYB22252）
