中山大学学报（医学科学版）2025，Vol.46Issue(4)：598-606,9.
无缺血肝移植技术的临床应用
Clinical Application of Ischemia-free Liver Transplantation
摘要
Abstract
Liver transplantation remains the optimal clinical treatment for patients with terminal liver diseases.Decades of persistent efforts from experts worldwide have propelled continuous innovation and advancement in this field.Chinese liver transplantation teams have achieved significant progress in the clinical liver transplantation.As organ transplantation enters its Era 2.0,ischemia-free organ transplantation has been expanded beyond the liver to include heart,lung,kidney and other transplantations,demonstrating broad application potential.Ischemia-free liver transplantation(ILFT)mitigates cell damage and postoperative complications associated with ischemia-reperfusion injury by maintaining continuous blood perfusion of the donor liver throughout procurement,preservation,and transplantation.This innovation also expands the utilization of marginal donor livers(e.g.,those from aged donors or with adipose infiltration),thereby alleviating donor shortage.Despite these advantages,ILFT faces challenges,including technical complexity,high equipment costs,and the absence of large-scale,multicenter long-term follow-up data.More effort should be put into optimizing portable perfusion systems,establishing standardized protocols,and investigating the synergistic potential of ILFT with immunomodulatory therapies.As the ILFT technology matures,it will improve liver transplantation outcomes,expand the donor pool,and enhance recipients'quality of life.This review presents the development of ILFT,criteria for donor and recipient selection,surgical techniques,and postoperative complications to lay a foundation for its broader clinical application.关键词
肝移植/缺血—再灌注损伤/无缺血/供受者选择/边缘供肝/术后并发症Key words
liver transplantation/ischemia-reperfusion injury/ischemia-free/selection of donor and recipient/marginal donor liver/postoperative complications分类
医药卫生引用本文复制引用
朱明强,王小华..无缺血肝移植技术的临床应用[J].中山大学学报（医学科学版）,2025,46(4):598-606,9.基金项目
赣州市卫生健康委员会市级科研计划项目(2022-2-074) （2022-2-074）
