中国现代医生2025，Vol.63Issue(19)：1-5,5.DOI:10.3969/j.issn.1673-9701.2025.19.001
25-羟维生素D与强直性脊柱炎的因果关系:双向孟德尔随机化研究
Causal relationship between 25-hydroxyvitamin D and ankylosing spondylitis:A two-way Mendelian randomization study
摘要
Abstract
Objective To explore causal relationship between 25-hydroxyvitamin D[25(OH)D]and ankylosing spondylitis(AS).Methods Genetic data of 25(OH)D and AS were extracted from the genome-wide association study.The causal effect of 25(OH)D on AS was estimated by MR-Egger regression method,weighted median,inverse variance weighted(IVW),simple mode and weighted mode,and sensitivity analysis was conducted for verification.Results The IVW results indicated that there was a causal relationship between 25(OH)D concentration and AS(OR=0.805,95％CI:0.686-0.944,P=0.008),and the maximum likelihood ratio(OR=0.799,95％CI:0.678-0.940,P=0.007)showed consistent results.The IVW results of the reverse Mendelian randomization study showed that there was no causal relationship between the two(OR=1.019,95％CI:0.995-1.043,P=0.110).In addition,MR-Egger intercept,Cochran Q test,"leave-one-out"and MR-PRESSO analysis showed no horizontal pleipotency or heterogeneity.Conclusion There may be a genetic causal relationship between the concentration of 25(OH)D and the onset of AS.AS cannot cause changes in the concentration of 25(OH)D in the body.关键词
25-羟维生素D/强直性脊柱炎/孟德尔随机化/因果关系Key words
25-hydroxyvitamin D/Ankylosing spondylitis/Mendelian randomization/Causality分类
医药卫生引用本文复制引用
熊浪,蔡珊燕,蒋总,兰维娅,唐芳,马武开,陈学勇,蔡珊珊,涂海霞,代雨晴..25-羟维生素D与强直性脊柱炎的因果关系:双向孟德尔随机化研究[J].中国现代医生,2025,63(19):1-5,5.基金项目
贵州省科技计划项目(黔科合平台人才[2020]2202) （黔科合平台人才[2020]2202）
