摘要
Abstract
Objective To explore the diagnostic value of platelet to hemoglobin ratio(PHR),lymphocyte to monocyte ratio(LMR),and apolipoprotein A1(ApoA1)in patients with breast cancer.Methods A total of 250 breast cancer patients diagnosed and treated in the First Affiliated Hospital of Guangxi Medical University from January 2022 to October 2023 were selected and included in breast cancer group,and 192 healthy women who underwent physical examinations at the hospital's health examination center during the same period were included in control group.To analyze the correlations between PHR,LMR and ApoA1 and the histopathological type,molecular subtype,tumor grade,stage,tumor size and lymphatic metastasis of breast cancer.The receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic value of ApoA1,PHR and LMR alone and combination in the detection of breast cancer.Results The peripheral blood PHR of patients in breast cancer group was significantly higher than that in control group(P＜0.001),while LMR and ApoA1 were significantly lower than those in control group(P＜0.001).The Pearson chi-square test results showed that peripheral blood PHR was significantly correlated with tumor size(x2=6.870,P＜0.05),while the correlations between LMR,ApoAl and pathological features of breast cancer were not obvious.The ROC curve analysis showed that the area under the curve(AUC)for the single diagnosis of breast cancer using peripheral blood PHR,LMR and ApoA1 were 0.665,0.645 and 0.733 respectively,and the optimal cut-off values were 2.01,5.34 and 1.335g/L.The AUC obtained by using the three indicators together was 0.794,with a sensitivity of 79.2％and a specificity of 67.2％.Conclusion Peripheral blood PHR,LMR and ApoA1 tests can all serve as potential indicators for the auxiliary diagnosis of breast cancer,and the combined use of these three tests has a relatively high diagnostic value.关键词
乳腺癌/血小板与血红蛋白比值/淋巴细胞与单核细胞比值/载脂蛋白A1Key words
Breast cancer/Platelet to hemoglobin ratio/Lymphocyte to monocyte ratio/Apolipoprotein A1分类
医药卫生
