植物学报2025，Vol.60Issue(4)：499-514,16.DOI:10.11983/CBB24103
植物线粒体铁硫簇合成系统及其调控的研究进展
Research Progress on the Iron-sulfur Cluster Synthesis System and Regulation in Plant Mitochondria
摘要
Abstract
Iron-sulfur[Fe-S]clusters,which act as cofactors for iron-sulfur proteins,are ubiquitously implicated in a di-verse array of biological processes,such as photosynthesis,respiration,electron transport,and the biosynthesis of es-sential vitamins and cofactors.Their intracellular biogenesis is modulated by a suite of proteins that catalyze and regulate the process,with compartmentalization occurring within discrete subcellular compartments.Mitochondria,as the central organelles for cellular energy metabolism,harbor numerous key metabolic enzymes that are iron-sulfur proteins,neces-sitating the provision of iron-sulfur clusters by the mitochondrial assembly machinery,the iron-sulfur cluster(ISC).Ad-vancements in research,particularly from bacteria and yeast systems,have facilitated significant strides in the identifica-tion and functional characterization of pivotal catalytic and regulatory proteins within the plant mitochondrial ISC system.Additionally,considerable progress has been made in the research of the role in iron-sulfur clusters in the plant growth and development.The elucidation of plant-specific components within the iron-sulfur cluster synthesis machinery and the mechanisms by which this system responds to environmental stress are areas of growing interest.This manuscript pro-vides a comprehensive review of the current state of research on the mechanism of iron-sulfur cluster synthesis in plants,with a particular focus on the mitochondrial ISC assembly system.It also provides a succinct synopsis of the role of key genes within the ISC system in plant growth and development,as well as their involvement in the response to abiotic stressors.关键词
铁硫簇/线粒体/ISC系统/植物/胁迫响应Key words
iron-sulfur clusters/mitochondria/ISC system/plants/stress response引用本文复制引用
谢涛,章一帆,刘云辉,游慧玉,夏季奔奔,马蓉,张春妮,华学军..植物线粒体铁硫簇合成系统及其调控的研究进展[J].植物学报,2025,60(4):499-514,16.基金项目
国家自然科学基金(No.32170307) （No.32170307）
