摘要
Abstract
Objective:To investigate the application value of laparoscopic gallstones surgery in the patients with gallstones.Method:90 patients with gallstones surgery from January 2023 to March 2024 were divided into control group(n=45)and observation group(n=45)according to the method of random number table.The control group were treated with small incision surgery,and the observation group were treated with laparoscopic gallstones surgery.Then the operation time,blood loss,hospitalization time,complication rates,cholecystokinin(CCK)and its receptor,inflammatory mediators[cytokines interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α),interleukin-8(IL-8)and other inflammatory mediators prostaglandin E2(PGE2)and platelet-activating factor(PAF)]before and after the surgery of two groups were compared.Result:The operation time of two groups were compared,and the difference was not statistically significant(P>0.05),and the hospitalization time of observation group was significantly shorter than that of control group,the blood loss was significantly less than that of control group,the total complication rate was significantly lower than that of control group,and the differences were statistically significant(P<0.05).The CCK and its receptor,cytokines and other inflammatory mediators of two groups before the surgery were compared,and the differences were not statistically significant(P>0.05).The CCK and its receptor of observation group 1 d and 3 d after the surgery were significantly higher than those of control group,the cytokines and other inflammatory mediators were significantly lower than those of control group,and the differences were statistically significant(P<0.05).Conclusion:Among patients undergoing gallstone surgery,laparoscopic surgery has better surgical indicators and lower complications.The expression changes of CCK,its receptors and inflammatory mediators during the perioperative period are different from those of small incision surgery.It is more suitable for patients undergoing gallstone surgery.关键词
腹腔镜手术/胆结石/围手术期/胆囊收缩素及其受体/炎症介质Key words
Laparoscopic surgery/Gallstone/Perioperative period/CCK and its receptor/Inflammatory mediators
