摘要
Abstract
Objective:To investigate the therapeutic effect of tanshinone IIA sodium sulfonate combined with amiodarone hydrochloride on ventricular arrhythmia(VA).Method:98 VA patients treated in Qianjiang Central Hospital from January 2023 to January 2024 were selected and divided into combination group and routine group,with 49 cases in each group according to random number table method.The conventional group was treated with amiodarone hydrochloride injection,and the combined group was treated with tanshinone ⅡA sodium sulfonate injection.The clinical efficacy and adverse drug reactions were compared between the two groups.HRV[global standard deviation during sinus R-R(SDNN),mean standard deviation during RR(SDANN),root mean square of the difference between adjacent normal RR periods(RMSSD)],B-type natriuretic peptide(BNP),cardiac function indicators[left ventricular ejection fraction(LVEF),heart index(CI)]and 6 min walking distance(6MWD),cardiac function grade,inflammatory markers[tumor necrosis factor-α(TFN-α),interleukin-6(IL-6),C-reactive protein(CRP)]were compared between the two groups before and after treatment.Result:The clinical effect of the combined group was significantly better than that of the conventional group,and the difference was statistically significant(P<0.05).After treatment,SDNN,SDANN,RMSSD,LVEF,CI and 6MWD were increased in 2 groups,the combined group was higher than the conventional group,and the difference was statistically significant(P<0.05).After treatment,BNP,TFN-α,IL-6 and CRP in 2 groups were decreased,the combined group was lower than the conventional group,and the difference was statistically significant(P<0.05).After treatment,the cardiac function grade of the combined group was significantly better than that of the conventional group,and the proportion of grade Ⅱ in the combined group was higher than that of the conventional group,the proportion of grade Ⅲ was lower than that of the conventional group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse drug reactions between the two groups(P>0.05).Conclusion:Tanshinone ⅡA sodium sulfonate injection combined with amiodarone hydrochloride injection can improve heart function and heart rate variability in VA patients,promote myocardial function recovery,and reduce inflammation.The side effects are mild.关键词
丹参酮ⅡA磺酸钠注射液/盐酸胺碘酮注射液/室性心律失常/疗效/心率变异性Key words
Tanshinone ⅡA sodium sulfonate injection/Amiodarone hydrochloride injection/Ventricular arrhythmia/Curative effect/Heart rate variability
