中西医结合肝病杂志2025，Vol.35Issue(7)：817-822,6.DOI:10.3969/j.issn.1005-0264.2025.007.006
代谢相关脂肪性肝病患者临床特征及数字疗法的干预效果分析
The clinical characteristics of patients with metabolic dysfunction-associated fatty liver disease(MAFLD)and effect of digital therapy on MAFLD
摘要
Abstract
Objective:To investigate the clinical characteristics of patients with metabolic dysfunction-associated fatty liver disease(MAFLD)and the effect of digital therapy on MAFLD.Methods:The physical examination population analyzed in the study who were evaluated by liver instantaneous elastic imaging in the physical examination center of the Fifth People's Hospital of Chongqing from May 2020 to December 2020.The patients who visited the fatty liver clinic of our hospital from May 2020 to September 2022 were retrospectively analyzed and divided into the lifestyle intervention group and the digital therapy group.Digital therapy is a closed-loop health management for MAFLD patients before,during,and after intervention on the basis of moderate diet and moderate exercise using an application program(APP)management platform.The gender,age,blood pressure,body mass index(BMI),body fat rate,waist circumference,alanine aminotransferase(ALT),aspartate aminotransferase(AST),gamma-glutamyl transpeptidase(GGT),total cholesterol(TC),triglyceride(TG),uric acid(UA),fasting blood glucose(FBG)and liver controlled attenuation parameter(CAP)were analyzed in the physical examination population and MAFLD patients.Results:Among 1 330 cases,72.9％were males(969/1 330),the average age was 55±13.9 years old,61％were overweight and obese(811/1 330),69.4％were fatty liver(923/1 330).The patients with moderate and severe fatty liver accounted for 80.8％(746/923)of the patients with fatty liver,and the patients with fatty liver were as high as 82.6％(670/811)of the overweight and obese people.There were statistically significant differences,respectively,in gender,age,hypertension,ALT,AST,TG,UA,FBG,and CAP among different BMI(P＜0.05).There were statistically significant differences,respectively,in age,BMI,hypertension,ALT,AST,TG,TC,UA and FBG among patients with different degrees of MAFLD(P＜0.05).After 26 weeks of digital therapy,the outcomes were improvements in BMI,body fat percentage,waist circumference,ALT,AST,GGT、TG,TC,UA,FBG,and CAP compared with those of 205 patients with MAFLD before treatment,with statistical significance,respectively(P＜0.05).The differences in differentials of BMI,body fat rate,waist circumference,FBG,and CAP before and after 26 weeks of digital therapy were statistically significant,respectively,compared with those of MAFLD patients before and after 26 weeks of lifestyle intervention(P＜0.05).Conclusion:The proportion of overweight and obesity is higher in men in the physical examination population.Overweight and obese patients are more likely to suffer from MAFLD,and the risk of high TC,high TG,high UA,and high FBG is higher in patients with MAFLD.Digital therapy can effectively improve the clinical prognosis of MAFLD patients,reduce body weight and body fat contents,and reduce waist circumference,reduce blood glucose level and liver steatosis.关键词
代谢相关脂肪性肝病/体质量指数/数字疗法/健康生活方式Key words
metabolic dysfunction-associated fatty liver disease/body mass index/digital therapy/health lifestyle分类
医药卫生引用本文复制引用
黄光明,刘钦,陈萍..代谢相关脂肪性肝病患者临床特征及数字疗法的干预效果分析[J].中西医结合肝病杂志,2025,35(7):817-822,6.基金项目
国家重点研发计划"智能传感器"重点专项(No.2022YFB3203700),南岸区科卫联合课题(No.2021-28) （No.2022YFB3203700）
