中医学报（英文）2025，Vol.5Issue(2)：94-100,7.DOI:10.1055/s-0045-1809320.ISSN 2096-918X
黄芪有效成分对胰岛β细胞的保护作用研究进展
Research Progress on the Protective Effects of Active Components of Huangqi(Astragali Radix)on Pancreatic β-Cells
摘要
Abstract
The potential application of Huangqi(Astragali Radix)in the treatment of diabetes mellitus(DM)has garnered increasing attention.β-cell dysfunction is one of the core mechanisms in the pathogenesis of DM and effectively protecting and restoring pancreatic β-cell function remains a key challenge in DM prevention and treatment.Studies have shown that the active components of Huangqi(Astragali Radix)can alleviate glucolipotoxicity-induced β-cell damage by promoting glucose uptake medi-ated by glucose transporter 4(GLUT-4),inhibiting the Wnt1/β-catenin signaling pathway to reduce lipid deposition in liver and pancreatic tissues and upregulating peroxisome proliferator-activated receptor α(PPARα)gene expression.Additionally,Huangqi(Astragali Radix)can reduce cell apoptosis by mitigating endoplasmic reticulum stress,suppress pyroptosis via the NF-κB/NLRP3/TXNIP signaling pathway,and inhibit ferroptosis and autophagy to decrease β-cell death.Furthermore,Huangqi(Astragali Radix)can promote β-cell proliferation by modulating dedifferentiation and transdifferentiation,improve the islet microenvironment by regulating immune function and reducing M1 macrophage polarization,and may delay β-cell senescence.This review summarizes the research progress of active ingredients in Huangqi(Astragali Radix)in protecting pancreatic β-cell,which provides new insights and a scientific basis for its future application in DM prevention and treatment.关键词
黄芪/胰岛β细胞/糖尿病/糖脂代谢/细胞死亡/衰老Key words
Huangqi/Astragali Radix/pancreatic β-cells/diabetes mellitus/glucose and lipid metabolism/cell death/senescence引用本文复制引用
颜利伊,李振华,陈源..黄芪有效成分对胰岛β细胞的保护作用研究进展[J].中医学报（英文）,2025,5(2):94-100,7.基金项目
This work was supported by National Natural Science Foundation of China(81774304),Shaanxi Traditional Chinese Medicine Administration Research Project(SZY-KJCYC-2025-JC-016),Qinchuangyuan Traditional Chinese Medicine Industrial Innovation Cluster Project(L2024-QCY-ZYYJJQ-X85),and Xianyang Science and Technology Bureau Key R&D Program(L2022ZDYFSF003). （81774304）
